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Bridging the gap between epigenetics research and nutritional public health interventions
Epigenetic processes, primarily DNA methylation and covalent modifications of histones, regulate the transcriptional activity of genes in a manner that can be modified by environmental cues. This allows variation in the expression of the transcriptome without changes in the genome. Constraint in the...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016622/ https://www.ncbi.nlm.nih.gov/pubmed/21067534 http://dx.doi.org/10.1186/gm201 |
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author | Burdge, Graham C Lillycrop, Karen A |
author_facet | Burdge, Graham C Lillycrop, Karen A |
author_sort | Burdge, Graham C |
collection | PubMed |
description | Epigenetic processes, primarily DNA methylation and covalent modifications of histones, regulate the transcriptional activity of genes in a manner that can be modified by environmental cues. This allows variation in the expression of the transcriptome without changes in the genome. Constraint in the early life environment, such as poor early nutrition, is associated with increased risk of non-communicable diseases, including cardio-metabolic disease and cancer in later life. Such induced phenotypic change involves environmental signals acting through developmental plasticity. Recent studies in humans and in animal models show that epigenetic processes, in particular DNA methylation, have a central role in the induction and stability of novel phenotypes and in increased disease risk. Identification of such processes suggests the potential for developing biomarkers of disease risk and for interventions to prevent or reverse the adverse effects of a poor early life environment. At present, knowledge in this area is limited to proof-of-principle studies in animal models and some initial studies in humans. Before such findings can be translated into reliable biomarkers and safe, effective interventions, several fundamental questions need to be answered. In order to achieve this, new technologies will be needed to support large cohort studies. Despite the early stage of knowledge in this field and the intellectual, technological and financial challenges, epigenetic research has substantial potential for public health benefits. |
format | Text |
id | pubmed-3016622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30166222011-11-05 Bridging the gap between epigenetics research and nutritional public health interventions Burdge, Graham C Lillycrop, Karen A Genome Med Commentary Epigenetic processes, primarily DNA methylation and covalent modifications of histones, regulate the transcriptional activity of genes in a manner that can be modified by environmental cues. This allows variation in the expression of the transcriptome without changes in the genome. Constraint in the early life environment, such as poor early nutrition, is associated with increased risk of non-communicable diseases, including cardio-metabolic disease and cancer in later life. Such induced phenotypic change involves environmental signals acting through developmental plasticity. Recent studies in humans and in animal models show that epigenetic processes, in particular DNA methylation, have a central role in the induction and stability of novel phenotypes and in increased disease risk. Identification of such processes suggests the potential for developing biomarkers of disease risk and for interventions to prevent or reverse the adverse effects of a poor early life environment. At present, knowledge in this area is limited to proof-of-principle studies in animal models and some initial studies in humans. Before such findings can be translated into reliable biomarkers and safe, effective interventions, several fundamental questions need to be answered. In order to achieve this, new technologies will be needed to support large cohort studies. Despite the early stage of knowledge in this field and the intellectual, technological and financial challenges, epigenetic research has substantial potential for public health benefits. BioMed Central 2010-11-05 /pmc/articles/PMC3016622/ /pubmed/21067534 http://dx.doi.org/10.1186/gm201 Text en Copyright ©2010 BioMed Central Ltd. |
spellingShingle | Commentary Burdge, Graham C Lillycrop, Karen A Bridging the gap between epigenetics research and nutritional public health interventions |
title | Bridging the gap between epigenetics research and nutritional public health interventions |
title_full | Bridging the gap between epigenetics research and nutritional public health interventions |
title_fullStr | Bridging the gap between epigenetics research and nutritional public health interventions |
title_full_unstemmed | Bridging the gap between epigenetics research and nutritional public health interventions |
title_short | Bridging the gap between epigenetics research and nutritional public health interventions |
title_sort | bridging the gap between epigenetics research and nutritional public health interventions |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016622/ https://www.ncbi.nlm.nih.gov/pubmed/21067534 http://dx.doi.org/10.1186/gm201 |
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