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Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species

Common chromosomal fragile sites FRA3B and FRA16D are frequent sites of DNA instability in cancer, but their contribution to cancer cell biology is not yet understood. Genes that span these sites (FHIT and WWOX, respectively) are often perturbed (either increased or decreased) in cancer cells and bo...

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Detalles Bibliográficos
Autores principales:	O'Keefe, Louise V., Colella, Alex, Dayan, Sonia, Chen, Qingwen, Choo, Amanda, Jacob, Reuben, Price, Gareth, Venter, Deon, Richards, Robert I.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016910/ https://www.ncbi.nlm.nih.gov/pubmed/21075834 http://dx.doi.org/10.1093/hmg/ddq495

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