The C-Terminus of H-Ras as a Target for the Covalent Binding of Reactive Compounds Modulating Ras-Dependent Pathways

Ras proteins are crucial players in differentiation and oncogenesis and constitute important drug targets. The localization and activity of Ras proteins are highly dependent on posttranslational modifications at their C-termini. In addition to an isoprenylated cysteine, H-Ras, but not other Ras prot...

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Detalles Bibliográficos
Autores principales: Oeste, Clara L., Díez-Dacal, Beatriz, Bray, Francesca, García de Lacoba, Mario, de la Torre, Beatriz G., Andreu, David, Ruiz-Sánchez, Antonio J., Pérez-Inestrosa, Ezequiel, García-Domínguez, Carlota A., Rojas, José M., Pérez-Sala, Dolores
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017061/
https://www.ncbi.nlm.nih.gov/pubmed/21253588
http://dx.doi.org/10.1371/journal.pone.0015866

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