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Structural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57

The herpesvirus proteins HSV-1 ICP27 and HVS ORF57 promote viral mRNA export by utilizing the cellular mRNA export machinery. This function is triggered by binding to proteins of the transcription-export (TREX) complex, in particular to REF/Aly which directs viral mRNA to the TAP/NFX1 pathway and, s...

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Detalles Bibliográficos
Autores principales:	Tunnicliffe, Richard B., Hautbergue, Guillaume M., Kalra, Priti, Jackson, Brian R., Whitehouse, Adrian, Wilson, Stuart A., Golovanov, Alexander P.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017119/ https://www.ncbi.nlm.nih.gov/pubmed/21253573 http://dx.doi.org/10.1371/journal.ppat.1001244

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