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Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements

p53 coordinates the expression of an intricate network of genes in response to stress signals. Sequence-specific DNA binding is essential for p53-mediated tumor suppression. We evaluated the impact of single-nucleotide polymorphisms (SNPs) in p53 response elements (p53RE) on DNA binding and gene exp...

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Detalles Bibliográficos
Autores principales:	Bandele, Omari J., Wang, Xuting, Campbell, Michelle R., Pittman, Gary S., Bell, Douglas A.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017610/ https://www.ncbi.nlm.nih.gov/pubmed/20817676 http://dx.doi.org/10.1093/nar/gkq764

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