Cargando…
Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium: Dual regulation of protein synthesis and degradation by Int6
INT6/EIF3E has been implicated in breast tumorigenesis, but its functional activities remain poorly defined. We found that repressing INT6 expression induced transformed properties in normal human mammary epithelium (MCF10A); in contrast, Int6 silencing induced apoptosis in HeLa cells. As in yeast,...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017639/ https://www.ncbi.nlm.nih.gov/pubmed/20890303 http://dx.doi.org/10.1038/onc.2010.445 |