Reduced Levofloxacin Susceptibility in Clinical Respiratory Isolates of Haemophilus Influenzae Is Not yet Associated with Mutations in the DNA Gyrase and Topoisomerase II Genes in Korea

Among 155 clinical respiratory isolates of Haemophilus influenzae in Korea, 6 (3.9%) isolates had reduced levofloxacin susceptibility (MICs ≥ 0.5 µg/mL). These six isolates had no significant quinolone resistance-determining region (QRDR) mutations in gyrA, gyrB, parC, or parE. This phenomenon sugge...

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Autores principales: Kim, In-Suk, Lee, Nam Yong, Kim, Sunjoo, Ki, Chang-Seok, Kim, Sun-Hee
Formato: Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2011
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017696/
https://www.ncbi.nlm.nih.gov/pubmed/21155053
http://dx.doi.org/10.3349/ymj.2011.52.1.188
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author Kim, In-Suk
Lee, Nam Yong
Kim, Sunjoo
Ki, Chang-Seok
Kim, Sun-Hee
author_facet Kim, In-Suk
Lee, Nam Yong
Kim, Sunjoo
Ki, Chang-Seok
Kim, Sun-Hee
author_sort Kim, In-Suk
collection PubMed
description Among 155 clinical respiratory isolates of Haemophilus influenzae in Korea, 6 (3.9%) isolates had reduced levofloxacin susceptibility (MICs ≥ 0.5 µg/mL). These six isolates had no significant quinolone resistance-determining region (QRDR) mutations in gyrA, gyrB, parC, or parE. This phenomenon suggests that neither evolution nor spread of any significant QRDRs mutations in clinical isolates occurred in Korea. Therefore, continued surveillance is necessary to observe the evolution of antibiotic-resistance and take measures to avoid the spread of drug-resistant clones.
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spelling pubmed-30176962011-01-10 Reduced Levofloxacin Susceptibility in Clinical Respiratory Isolates of Haemophilus Influenzae Is Not yet Associated with Mutations in the DNA Gyrase and Topoisomerase II Genes in Korea Kim, In-Suk Lee, Nam Yong Kim, Sunjoo Ki, Chang-Seok Kim, Sun-Hee Yonsei Med J Brief Communication Among 155 clinical respiratory isolates of Haemophilus influenzae in Korea, 6 (3.9%) isolates had reduced levofloxacin susceptibility (MICs ≥ 0.5 µg/mL). These six isolates had no significant quinolone resistance-determining region (QRDR) mutations in gyrA, gyrB, parC, or parE. This phenomenon suggests that neither evolution nor spread of any significant QRDRs mutations in clinical isolates occurred in Korea. Therefore, continued surveillance is necessary to observe the evolution of antibiotic-resistance and take measures to avoid the spread of drug-resistant clones. Yonsei University College of Medicine 2011-01-01 2010-11-30 /pmc/articles/PMC3017696/ /pubmed/21155053 http://dx.doi.org/10.3349/ymj.2011.52.1.188 Text en © Copyright: Yonsei University College of Medicine 2011 http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Kim, In-Suk
Lee, Nam Yong
Kim, Sunjoo
Ki, Chang-Seok
Kim, Sun-Hee
Reduced Levofloxacin Susceptibility in Clinical Respiratory Isolates of Haemophilus Influenzae Is Not yet Associated with Mutations in the DNA Gyrase and Topoisomerase II Genes in Korea
title Reduced Levofloxacin Susceptibility in Clinical Respiratory Isolates of Haemophilus Influenzae Is Not yet Associated with Mutations in the DNA Gyrase and Topoisomerase II Genes in Korea
title_full Reduced Levofloxacin Susceptibility in Clinical Respiratory Isolates of Haemophilus Influenzae Is Not yet Associated with Mutations in the DNA Gyrase and Topoisomerase II Genes in Korea
title_fullStr Reduced Levofloxacin Susceptibility in Clinical Respiratory Isolates of Haemophilus Influenzae Is Not yet Associated with Mutations in the DNA Gyrase and Topoisomerase II Genes in Korea
title_full_unstemmed Reduced Levofloxacin Susceptibility in Clinical Respiratory Isolates of Haemophilus Influenzae Is Not yet Associated with Mutations in the DNA Gyrase and Topoisomerase II Genes in Korea
title_short Reduced Levofloxacin Susceptibility in Clinical Respiratory Isolates of Haemophilus Influenzae Is Not yet Associated with Mutations in the DNA Gyrase and Topoisomerase II Genes in Korea
title_sort reduced levofloxacin susceptibility in clinical respiratory isolates of haemophilus influenzae is not yet associated with mutations in the dna gyrase and topoisomerase ii genes in korea
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017696/
https://www.ncbi.nlm.nih.gov/pubmed/21155053
http://dx.doi.org/10.3349/ymj.2011.52.1.188
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