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DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis

In the autoimmune syndrome rheumatoid arthritis (RA), T cells and T-cell precursors have age-inappropriate shortening of telomeres and accumulate deoxyribonucleic acid (DNA) double strand breaks. Whether damaged DNA elicits DNA repair activity and how this affects T-cell function and survival is unk...

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Detalles Bibliográficos
Autores principales:	Shao, Lan, Goronzy, Jörg J, Weyand, Cornelia M
Formato:	Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2010
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017722/ https://www.ncbi.nlm.nih.gov/pubmed/20878914 http://dx.doi.org/10.1002/emmm.201000096

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