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Use of ß-blocker therapy to prevent primary bleeding of esophageal varices
Purpose: The purpose of this article is to educate nurse practitioners about the pathophysiology surrounding the development of portal hypertension and the effective use of nonselective ß-blockers to prevent primary bleeding and decrease the mortality risk. Data sources: The articles included were r...
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Formato: | Texto |
Lenguaje: | English |
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Blackwell Publishing Inc
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017746/ https://www.ncbi.nlm.nih.gov/pubmed/21129071 http://dx.doi.org/10.1111/j.1745-7599.2010.00567.x |
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author | Tursi, Tammy |
author_facet | Tursi, Tammy |
author_sort | Tursi, Tammy |
collection | PubMed |
description | Purpose: The purpose of this article is to educate nurse practitioners about the pathophysiology surrounding the development of portal hypertension and the effective use of nonselective ß-blockers to prevent primary bleeding and decrease the mortality risk. Data sources: The articles included were retrieved via ISI Web of Science using the years 2004–2009 and key words cirrhosis, portal hypertension, esophageal varices, and beta-blockers. This information included scholarly books, journal reviews, retrospective chart reviews, and prospective randomized studies. Conclusions: Cirrhosis is the leading cause of portal hypertension in Europe and North America. Esophageal varices are a result of the portosystemic collaterals the body develops to decompress the portal system. Hemorrhage from esophageal varices is a major cause of morbidity and mortality. Prevention of a primary bleed is the goal of therapy and is accomplished with nonselective ß-blockers. Implications for practice: Very few patients with portal hypertension and esophageal varices are on ß-blockers. Use of nonselective ß-blockers has been found to lower portal pressure and decreases the risk of bleeding from esophageal varices and therefore decreases mortality. Patients unable to use ß-blockers can undergo endoscopic variceal ligation as an alternate method to reduce risk of bleeding. |
format | Text |
id | pubmed-3017746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Blackwell Publishing Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-30177462011-01-19 Use of ß-blocker therapy to prevent primary bleeding of esophageal varices Tursi, Tammy J Am Acad Nurse Pract Ce Article Purpose: The purpose of this article is to educate nurse practitioners about the pathophysiology surrounding the development of portal hypertension and the effective use of nonselective ß-blockers to prevent primary bleeding and decrease the mortality risk. Data sources: The articles included were retrieved via ISI Web of Science using the years 2004–2009 and key words cirrhosis, portal hypertension, esophageal varices, and beta-blockers. This information included scholarly books, journal reviews, retrospective chart reviews, and prospective randomized studies. Conclusions: Cirrhosis is the leading cause of portal hypertension in Europe and North America. Esophageal varices are a result of the portosystemic collaterals the body develops to decompress the portal system. Hemorrhage from esophageal varices is a major cause of morbidity and mortality. Prevention of a primary bleed is the goal of therapy and is accomplished with nonselective ß-blockers. Implications for practice: Very few patients with portal hypertension and esophageal varices are on ß-blockers. Use of nonselective ß-blockers has been found to lower portal pressure and decreases the risk of bleeding from esophageal varices and therefore decreases mortality. Patients unable to use ß-blockers can undergo endoscopic variceal ligation as an alternate method to reduce risk of bleeding. Blackwell Publishing Inc 2010-12 /pmc/articles/PMC3017746/ /pubmed/21129071 http://dx.doi.org/10.1111/j.1745-7599.2010.00567.x Text en © 2010 American Academy of Nurse Practitioners http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Ce Article Tursi, Tammy Use of ß-blocker therapy to prevent primary bleeding of esophageal varices |
title | Use of ß-blocker therapy to prevent primary bleeding of esophageal varices |
title_full | Use of ß-blocker therapy to prevent primary bleeding of esophageal varices |
title_fullStr | Use of ß-blocker therapy to prevent primary bleeding of esophageal varices |
title_full_unstemmed | Use of ß-blocker therapy to prevent primary bleeding of esophageal varices |
title_short | Use of ß-blocker therapy to prevent primary bleeding of esophageal varices |
title_sort | use of ß-blocker therapy to prevent primary bleeding of esophageal varices |
topic | Ce Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017746/ https://www.ncbi.nlm.nih.gov/pubmed/21129071 http://dx.doi.org/10.1111/j.1745-7599.2010.00567.x |
work_keys_str_mv | AT tursitammy useofßblockertherapytopreventprimarybleedingofesophagealvarices |