Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces

BACKGROUND: Interleukin-4 (IL4) is a secreted immunoregulatory cytokine critically involved in host protection from parasitic helminths [1]. Reasoning that helminths may have evolved mechanisms to antagonize IL4 to maximize their dispersal, we explored mammalian IL4 evolution. RESULTS: This analysis...

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Detalles Bibliográficos
Autores principales: Koyanagi, Madoka, Kerns, Julie A, Chung, Linda, Zhang, Yan, Brown, Scott, Moldoveanu, Tudor, Malik, Harmit S, Bix, Mark
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017759/
https://www.ncbi.nlm.nih.gov/pubmed/20649995
http://dx.doi.org/10.1186/1471-2148-10-223

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