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Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells

The goal of this paper is to construct a new algorithm for the numerical simulations of the evolution of tumour invasion and metastasis. By means of mathematical model equations and their numerical solutions we investigate how cancer cells can produce and secrete matrix degradative enzymes, degrade...

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Detalles Bibliográficos
Autores principales: Kolev, M., Zubik-Kowal, B.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017898/
https://www.ncbi.nlm.nih.gov/pubmed/21331265
http://dx.doi.org/10.1155/2011/452320
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author Kolev, M.
Zubik-Kowal, B.
author_facet Kolev, M.
Zubik-Kowal, B.
author_sort Kolev, M.
collection PubMed
description The goal of this paper is to construct a new algorithm for the numerical simulations of the evolution of tumour invasion and metastasis. By means of mathematical model equations and their numerical solutions we investigate how cancer cells can produce and secrete matrix degradative enzymes, degrade extracellular matrix, and invade due to diffusion and haptotactic migration. For the numerical simulations of the interactions between the tumour cells and the surrounding tissue, we apply numerical approximations, which are spectrally accurate and based on small amounts of grid-points. Our numerical experiments illustrate the metastatic ability of tumour cells.
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spelling pubmed-30178982011-02-17 Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells Kolev, M. Zubik-Kowal, B. Comput Math Methods Med Research Article The goal of this paper is to construct a new algorithm for the numerical simulations of the evolution of tumour invasion and metastasis. By means of mathematical model equations and their numerical solutions we investigate how cancer cells can produce and secrete matrix degradative enzymes, degrade extracellular matrix, and invade due to diffusion and haptotactic migration. For the numerical simulations of the interactions between the tumour cells and the surrounding tissue, we apply numerical approximations, which are spectrally accurate and based on small amounts of grid-points. Our numerical experiments illustrate the metastatic ability of tumour cells. Hindawi Publishing Corporation 2011 2010-12-30 /pmc/articles/PMC3017898/ /pubmed/21331265 http://dx.doi.org/10.1155/2011/452320 Text en Copyright © 2011 M. Kolev and B. Zubik-Kowal. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kolev, M.
Zubik-Kowal, B.
Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells
title Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells
title_full Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells
title_fullStr Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells
title_full_unstemmed Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells
title_short Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells
title_sort numerical solutions for a model of tissue invasion and migration of tumour cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017898/
https://www.ncbi.nlm.nih.gov/pubmed/21331265
http://dx.doi.org/10.1155/2011/452320
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