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Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells
The goal of this paper is to construct a new algorithm for the numerical simulations of the evolution of tumour invasion and metastasis. By means of mathematical model equations and their numerical solutions we investigate how cancer cells can produce and secrete matrix degradative enzymes, degrade...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017898/ https://www.ncbi.nlm.nih.gov/pubmed/21331265 http://dx.doi.org/10.1155/2011/452320 |
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author | Kolev, M. Zubik-Kowal, B. |
author_facet | Kolev, M. Zubik-Kowal, B. |
author_sort | Kolev, M. |
collection | PubMed |
description | The goal of this paper is to construct a new algorithm for the numerical simulations of the evolution of tumour invasion and metastasis. By means of mathematical model equations and their numerical solutions we investigate how cancer cells can produce and secrete matrix degradative enzymes, degrade extracellular matrix, and invade due to diffusion and haptotactic migration. For the numerical simulations of the interactions between the tumour cells and the surrounding tissue, we apply numerical approximations, which are spectrally accurate and based on small amounts of grid-points. Our numerical experiments illustrate the metastatic ability of tumour cells. |
format | Text |
id | pubmed-3017898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30178982011-02-17 Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells Kolev, M. Zubik-Kowal, B. Comput Math Methods Med Research Article The goal of this paper is to construct a new algorithm for the numerical simulations of the evolution of tumour invasion and metastasis. By means of mathematical model equations and their numerical solutions we investigate how cancer cells can produce and secrete matrix degradative enzymes, degrade extracellular matrix, and invade due to diffusion and haptotactic migration. For the numerical simulations of the interactions between the tumour cells and the surrounding tissue, we apply numerical approximations, which are spectrally accurate and based on small amounts of grid-points. Our numerical experiments illustrate the metastatic ability of tumour cells. Hindawi Publishing Corporation 2011 2010-12-30 /pmc/articles/PMC3017898/ /pubmed/21331265 http://dx.doi.org/10.1155/2011/452320 Text en Copyright © 2011 M. Kolev and B. Zubik-Kowal. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kolev, M. Zubik-Kowal, B. Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells |
title | Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells |
title_full | Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells |
title_fullStr | Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells |
title_full_unstemmed | Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells |
title_short | Numerical Solutions for a Model of Tissue Invasion and Migration of Tumour Cells |
title_sort | numerical solutions for a model of tissue invasion and migration of tumour cells |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017898/ https://www.ncbi.nlm.nih.gov/pubmed/21331265 http://dx.doi.org/10.1155/2011/452320 |
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