IGF-I and IGF Binding Protein-3 Generation Tests and Response to Growth Hormone in Children with Silver-Russell Syndrome

Objectives. To evaluate, in children with Silver-Russell Syndrome, the response to the IGF-I and IGFBP-3 generation test and compare results to the growth response after 6 months of rhGH. Methods. Eight children (6 males), with a mean age of 5.71 ± 2.48 years and height SDS of −3.88 ± 1.28 received...

Descripción completa

Detalles Bibliográficos
Autores principales: Beserra, Izabel C. R., Ribeiro, Márcia G., Collett-Solberg, Paulo F., Vaisman, Mário, Guimarães, Marília M.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017907/
https://www.ncbi.nlm.nih.gov/pubmed/21234390
http://dx.doi.org/10.1155/2010/546854
_version_ 1782195981784186880
author Beserra, Izabel C. R.
Ribeiro, Márcia G.
Collett-Solberg, Paulo F.
Vaisman, Mário
Guimarães, Marília M.
author_facet Beserra, Izabel C. R.
Ribeiro, Márcia G.
Collett-Solberg, Paulo F.
Vaisman, Mário
Guimarães, Marília M.
author_sort Beserra, Izabel C. R.
collection PubMed
description Objectives. To evaluate, in children with Silver-Russell Syndrome, the response to the IGF-I and IGFBP-3 generation test and compare results to the growth response after 6 months of rhGH. Methods. Eight children (6 males), with a mean age of 5.71 ± 2.48 years and height SDS of −3.88 ± 1.28 received rhGH for 6 months. IGF-I and IGFBP-3 were analyzed before and after 4 doses of rhGH. Results. The mean growth velocity (GV) before treatment was 5.28 ± 1.9 cm/year. GV increased after rhGH in five children to a mean GV of 10.3 ± 3.64 cm/year. Six children had normal basal IGF-I levels and two low levels. After 4 doses of rhGH, the IGF-I levels were normal in seven. There was no correlation between the growth response and the IGF-I generation test. Conclusions. Children with SRS have normal IGF-I generation test. There is no correlation between the generation test and the growth velocity after 6 months of rhGH.
format Text
id pubmed-3017907
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-30179072011-01-13 IGF-I and IGF Binding Protein-3 Generation Tests and Response to Growth Hormone in Children with Silver-Russell Syndrome Beserra, Izabel C. R. Ribeiro, Márcia G. Collett-Solberg, Paulo F. Vaisman, Mário Guimarães, Marília M. Int J Pediatr Endocrinol Clinical Study Objectives. To evaluate, in children with Silver-Russell Syndrome, the response to the IGF-I and IGFBP-3 generation test and compare results to the growth response after 6 months of rhGH. Methods. Eight children (6 males), with a mean age of 5.71 ± 2.48 years and height SDS of −3.88 ± 1.28 received rhGH for 6 months. IGF-I and IGFBP-3 were analyzed before and after 4 doses of rhGH. Results. The mean growth velocity (GV) before treatment was 5.28 ± 1.9 cm/year. GV increased after rhGH in five children to a mean GV of 10.3 ± 3.64 cm/year. Six children had normal basal IGF-I levels and two low levels. After 4 doses of rhGH, the IGF-I levels were normal in seven. There was no correlation between the growth response and the IGF-I generation test. Conclusions. Children with SRS have normal IGF-I generation test. There is no correlation between the generation test and the growth velocity after 6 months of rhGH. Hindawi Publishing Corporation 2010 2010-12-27 /pmc/articles/PMC3017907/ /pubmed/21234390 http://dx.doi.org/10.1155/2010/546854 Text en Copyright © 2010 Izabel C. R. Beserra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Beserra, Izabel C. R.
Ribeiro, Márcia G.
Collett-Solberg, Paulo F.
Vaisman, Mário
Guimarães, Marília M.
IGF-I and IGF Binding Protein-3 Generation Tests and Response to Growth Hormone in Children with Silver-Russell Syndrome
title IGF-I and IGF Binding Protein-3 Generation Tests and Response to Growth Hormone in Children with Silver-Russell Syndrome
title_full IGF-I and IGF Binding Protein-3 Generation Tests and Response to Growth Hormone in Children with Silver-Russell Syndrome
title_fullStr IGF-I and IGF Binding Protein-3 Generation Tests and Response to Growth Hormone in Children with Silver-Russell Syndrome
title_full_unstemmed IGF-I and IGF Binding Protein-3 Generation Tests and Response to Growth Hormone in Children with Silver-Russell Syndrome
title_short IGF-I and IGF Binding Protein-3 Generation Tests and Response to Growth Hormone in Children with Silver-Russell Syndrome
title_sort igf-i and igf binding protein-3 generation tests and response to growth hormone in children with silver-russell syndrome
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017907/
https://www.ncbi.nlm.nih.gov/pubmed/21234390
http://dx.doi.org/10.1155/2010/546854
work_keys_str_mv AT beserraizabelcr igfiandigfbindingprotein3generationtestsandresponsetogrowthhormoneinchildrenwithsilverrussellsyndrome
AT ribeiromarciag igfiandigfbindingprotein3generationtestsandresponsetogrowthhormoneinchildrenwithsilverrussellsyndrome
AT collettsolbergpaulof igfiandigfbindingprotein3generationtestsandresponsetogrowthhormoneinchildrenwithsilverrussellsyndrome
AT vaismanmario igfiandigfbindingprotein3generationtestsandresponsetogrowthhormoneinchildrenwithsilverrussellsyndrome
AT guimaraesmariliam igfiandigfbindingprotein3generationtestsandresponsetogrowthhormoneinchildrenwithsilverrussellsyndrome

Ejemplares similares