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Impairment of Methotrexate Transport Is Common in Osteosarcoma Tumor Samples

Osteosarcoma does not respond well to conventional dose methotrexate but does respond to high-dose methotrexate. Previous work has indicated that this resistance may be due to impaired transport of methotrexate across the cell membrane. In this study, the PT430 competitive displacement assay was ada...

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Detalles Bibliográficos
Autores principales:	Sowers, Rebecca, Wenzel, Bethanne D., Richardson, Condon, Meyers, Paul A., Healey, John H., Levy, Adam S., Gorlick, Richard
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017953/ https://www.ncbi.nlm.nih.gov/pubmed/21234348 http://dx.doi.org/10.1155/2011/834170

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