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Effect of Diabetes Mellitus on Outcomes of Colorectal Cancer
PURPOSE: Many studies have revealed that diabetes mellitus (DM) increases a person's lifetime risk of colorectal cancer and that DM is associated with a worse outcome of colon cancer, but this association is controversial. In this study, we intended to examine the relationship between DM and th...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Society of Coloproctology
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017979/ https://www.ncbi.nlm.nih.gov/pubmed/21221244 http://dx.doi.org/10.3393/jksc.2010.26.6.424 |
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author | Noh, Geum Youb Hwang, Dae-Yong Choi, Yoon Hee Lee, Yun Yong |
author_facet | Noh, Geum Youb Hwang, Dae-Yong Choi, Yoon Hee Lee, Yun Yong |
author_sort | Noh, Geum Youb |
collection | PubMed |
description | PURPOSE: Many studies have revealed that diabetes mellitus (DM) increases a person's lifetime risk of colorectal cancer and that DM is associated with a worse outcome of colon cancer, but this association is controversial. In this study, we intended to examine the relationship between DM and the long-term outcomes of colorectal cancer. METHODS: A retrospective analysis was conducted on 657 patients who underwent surgery due to colorectal cancer between 1997 and 2004 at Korea Cancer Center Hospital. The operations were done by a single surgeon. With a median follow-up of 4.7 years, we analyzed differences in recurrence-free survival (RFS) and overall survival (OS) between patients with DM and those without DM. RESULTS: Of the 657 patients, 374 (57%) were males and 67 (10%) had DM. There was no difference in age at diagnosis, sex and pathologic stage of colorectal cancer according to the presence of DM. There were no difference in the RFS and the OS of colon cancer between the patients with DM and those without DM. At 5 years, the RFS was 71.3% in diabetic patients vs. 70.4% in non-diabetic patients (P = 0.480), and the OS was 68.8% in diabetic patients vs. 75.0% in non-diabetic patients (P = 0.498). There was no difference in the median survival between the groups (9.6 years in the diabetic group vs. 10.6 years in the non-diabetic group; P = 0.495). CONCLUSION: In this study, we did not find any relation between the presence of DM and either the recurrence or the survival in cases of colorectal cancer. More studies to elucidate whether the influence of DM is directly related to a higher rate of cancer recurrence or survival are needed. |
format | Text |
id | pubmed-3017979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The Korean Society of Coloproctology |
record_format | MEDLINE/PubMed |
spelling | pubmed-30179792011-01-10 Effect of Diabetes Mellitus on Outcomes of Colorectal Cancer Noh, Geum Youb Hwang, Dae-Yong Choi, Yoon Hee Lee, Yun Yong J Korean Soc Coloproctology Original Article PURPOSE: Many studies have revealed that diabetes mellitus (DM) increases a person's lifetime risk of colorectal cancer and that DM is associated with a worse outcome of colon cancer, but this association is controversial. In this study, we intended to examine the relationship between DM and the long-term outcomes of colorectal cancer. METHODS: A retrospective analysis was conducted on 657 patients who underwent surgery due to colorectal cancer between 1997 and 2004 at Korea Cancer Center Hospital. The operations were done by a single surgeon. With a median follow-up of 4.7 years, we analyzed differences in recurrence-free survival (RFS) and overall survival (OS) between patients with DM and those without DM. RESULTS: Of the 657 patients, 374 (57%) were males and 67 (10%) had DM. There was no difference in age at diagnosis, sex and pathologic stage of colorectal cancer according to the presence of DM. There were no difference in the RFS and the OS of colon cancer between the patients with DM and those without DM. At 5 years, the RFS was 71.3% in diabetic patients vs. 70.4% in non-diabetic patients (P = 0.480), and the OS was 68.8% in diabetic patients vs. 75.0% in non-diabetic patients (P = 0.498). There was no difference in the median survival between the groups (9.6 years in the diabetic group vs. 10.6 years in the non-diabetic group; P = 0.495). CONCLUSION: In this study, we did not find any relation between the presence of DM and either the recurrence or the survival in cases of colorectal cancer. More studies to elucidate whether the influence of DM is directly related to a higher rate of cancer recurrence or survival are needed. The Korean Society of Coloproctology 2010-12 2010-12-31 /pmc/articles/PMC3017979/ /pubmed/21221244 http://dx.doi.org/10.3393/jksc.2010.26.6.424 Text en © 2010 The Korean Society of Coloproctology http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Noh, Geum Youb Hwang, Dae-Yong Choi, Yoon Hee Lee, Yun Yong Effect of Diabetes Mellitus on Outcomes of Colorectal Cancer |
title | Effect of Diabetes Mellitus on Outcomes of Colorectal Cancer |
title_full | Effect of Diabetes Mellitus on Outcomes of Colorectal Cancer |
title_fullStr | Effect of Diabetes Mellitus on Outcomes of Colorectal Cancer |
title_full_unstemmed | Effect of Diabetes Mellitus on Outcomes of Colorectal Cancer |
title_short | Effect of Diabetes Mellitus on Outcomes of Colorectal Cancer |
title_sort | effect of diabetes mellitus on outcomes of colorectal cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017979/ https://www.ncbi.nlm.nih.gov/pubmed/21221244 http://dx.doi.org/10.3393/jksc.2010.26.6.424 |
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