Repeatability of tissue fluorescence measurements for the detection of cervical intraepithelial neoplasia

We examined intensity and shape differences in 378 repeated spectroscopic measures of the cervix. We examined causes of variability such as presence of precancer or cancer, pathologic tissue type, menopausal status, hormone or oral contraceptive use, and age; as well as technology related variables...

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Detalles Bibliográficos
Autores principales: Yamal, José-Miguel, Cox, Dennis D., Atkinson, E. Neely, MacAulay, Calum, Price, Roderick, Follen, Michele
Formato: Texto
Lenguaje:English
Publicado: Optical Society of America 2010
Materias:
Optics in Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018008/
https://www.ncbi.nlm.nih.gov/pubmed/21258497
http://dx.doi.org/10.1364/BOE.1.000641
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author Yamal, José-Miguel
Cox, Dennis D.
Atkinson, E. Neely
MacAulay, Calum
Price, Roderick
Follen, Michele
author_facet Yamal, José-Miguel
Cox, Dennis D.
Atkinson, E. Neely
MacAulay, Calum
Price, Roderick
Follen, Michele
author_sort Yamal, José-Miguel
collection PubMed
description We examined intensity and shape differences in 378 repeated spectroscopic measures of the cervix. We examined causes of variability such as presence of precancer or cancer, pathologic tissue type, menopausal status, hormone or oral contraceptive use, and age; as well as technology related variables like generation of device and provider making exam. Age, device generation, and provider were statistically significantly related to intensity differences. Provider and device generation were related to shape differences. We examined the order of measurements and found a decreased intensity in the second measurement due to hemoglobin absorption. 96% of repeat measurements had classification concordance of cervical intraepithelial neoplasia.
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spelling pubmed-30180082011-01-21 Repeatability of tissue fluorescence measurements for the detection of cervical intraepithelial neoplasia Yamal, José-Miguel Cox, Dennis D. Atkinson, E. Neely MacAulay, Calum Price, Roderick Follen, Michele Biomed Opt Express Optics in Cancer Research We examined intensity and shape differences in 378 repeated spectroscopic measures of the cervix. We examined causes of variability such as presence of precancer or cancer, pathologic tissue type, menopausal status, hormone or oral contraceptive use, and age; as well as technology related variables like generation of device and provider making exam. Age, device generation, and provider were statistically significantly related to intensity differences. Provider and device generation were related to shape differences. We examined the order of measurements and found a decreased intensity in the second measurement due to hemoglobin absorption. 96% of repeat measurements had classification concordance of cervical intraepithelial neoplasia. Optical Society of America 2010-08-19 /pmc/articles/PMC3018008/ /pubmed/21258497 http://dx.doi.org/10.1364/BOE.1.000641 Text en ©2010 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Optics in Cancer Research
Yamal, José-Miguel
Cox, Dennis D.
Atkinson, E. Neely
MacAulay, Calum
Price, Roderick
Follen, Michele
Repeatability of tissue fluorescence measurements for the detection of cervical intraepithelial neoplasia
title Repeatability of tissue fluorescence measurements for the detection of cervical intraepithelial neoplasia
title_full Repeatability of tissue fluorescence measurements for the detection of cervical intraepithelial neoplasia
title_fullStr Repeatability of tissue fluorescence measurements for the detection of cervical intraepithelial neoplasia
title_full_unstemmed Repeatability of tissue fluorescence measurements for the detection of cervical intraepithelial neoplasia
title_short Repeatability of tissue fluorescence measurements for the detection of cervical intraepithelial neoplasia
title_sort repeatability of tissue fluorescence measurements for the detection of cervical intraepithelial neoplasia
topic Optics in Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018008/
https://www.ncbi.nlm.nih.gov/pubmed/21258497
http://dx.doi.org/10.1364/BOE.1.000641
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