Depth-resolved imaging and detection of micro-retroreflectors within biological tissue using Optical Coherence Tomography

A new approach to in vivo biosensor design is introduced, based on the use of an implantable micron-sized retroreflector-based platform and non-invasive imaging of its surface reflectivity by Optical Coherence Tomography (OCT). The possibility of using OCT for the depth-resolved imaging and detectio...

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Autores principales: Ivers, Steven N., Baranov, Stephan A., Sherlock, Tim, Kourentzi, Katerina, Ruchhoeft, Paul, Willson, Richard, Larin, Kirill V.
Formato: Texto
Lenguaje:English
Publicado: Optical Society of America 2010
Materias:
Novel Light Sources, Optics, and Detectors
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018009/
https://www.ncbi.nlm.nih.gov/pubmed/21258473
http://dx.doi.org/10.1364/BOE.1.000367
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author Ivers, Steven N.
Baranov, Stephan A.
Sherlock, Tim
Kourentzi, Katerina
Ruchhoeft, Paul
Willson, Richard
Larin, Kirill V.
author_facet Ivers, Steven N.
Baranov, Stephan A.
Sherlock, Tim
Kourentzi, Katerina
Ruchhoeft, Paul
Willson, Richard
Larin, Kirill V.
author_sort Ivers, Steven N.
collection PubMed
description A new approach to in vivo biosensor design is introduced, based on the use of an implantable micron-sized retroreflector-based platform and non-invasive imaging of its surface reflectivity by Optical Coherence Tomography (OCT). The possibility of using OCT for the depth-resolved imaging and detection of micro-retroreflectors in highly turbid media, including tissue, is demonstrated. The maximum imaging depth for the detection of the micro-retroreflector-based platform within the surrounding media was found to be 0.91 mm for porcine tissue and 1.65 mm for whole milk. With further development, it may be possible to utilize OCT and micro-retroreflectors as a tool for continuous monitoring of analytes in the subcutaneous tissue.
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spelling pubmed-30180092011-01-21 Depth-resolved imaging and detection of micro-retroreflectors within biological tissue using Optical Coherence Tomography Ivers, Steven N. Baranov, Stephan A. Sherlock, Tim Kourentzi, Katerina Ruchhoeft, Paul Willson, Richard Larin, Kirill V. Biomed Opt Express Novel Light Sources, Optics, and Detectors A new approach to in vivo biosensor design is introduced, based on the use of an implantable micron-sized retroreflector-based platform and non-invasive imaging of its surface reflectivity by Optical Coherence Tomography (OCT). The possibility of using OCT for the depth-resolved imaging and detection of micro-retroreflectors in highly turbid media, including tissue, is demonstrated. The maximum imaging depth for the detection of the micro-retroreflector-based platform within the surrounding media was found to be 0.91 mm for porcine tissue and 1.65 mm for whole milk. With further development, it may be possible to utilize OCT and micro-retroreflectors as a tool for continuous monitoring of analytes in the subcutaneous tissue. Optical Society of America 2010-08-02 /pmc/articles/PMC3018009/ /pubmed/21258473 http://dx.doi.org/10.1364/BOE.1.000367 Text en ©2010 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Novel Light Sources, Optics, and Detectors
Ivers, Steven N.
Baranov, Stephan A.
Sherlock, Tim
Kourentzi, Katerina
Ruchhoeft, Paul
Willson, Richard
Larin, Kirill V.
Depth-resolved imaging and detection of micro-retroreflectors within biological tissue using Optical Coherence Tomography
title Depth-resolved imaging and detection of micro-retroreflectors within biological tissue using Optical Coherence Tomography
title_full Depth-resolved imaging and detection of micro-retroreflectors within biological tissue using Optical Coherence Tomography
title_fullStr Depth-resolved imaging and detection of micro-retroreflectors within biological tissue using Optical Coherence Tomography
title_full_unstemmed Depth-resolved imaging and detection of micro-retroreflectors within biological tissue using Optical Coherence Tomography
title_short Depth-resolved imaging and detection of micro-retroreflectors within biological tissue using Optical Coherence Tomography
title_sort depth-resolved imaging and detection of micro-retroreflectors within biological tissue using optical coherence tomography
topic Novel Light Sources, Optics, and Detectors
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018009/
https://www.ncbi.nlm.nih.gov/pubmed/21258473
http://dx.doi.org/10.1364/BOE.1.000367
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