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Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans
Doppler optical coherence tomography has the capability to measure blood flow quantitatively and in vivo. As only the axial component of the velocity can be assessed, the measurements have to be corrected for the angle of the vessels. We present a novel approach to extract quantitative flow data fro...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Optical Society of America
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018083/ https://www.ncbi.nlm.nih.gov/pubmed/21258529 http://dx.doi.org/10.1364/BOE.1.001047 |
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author | Singh, Amardeep S. G. Kolbitsch, Christoph Schmoll, Tilman Leitgeb, Rainer A. |
author_facet | Singh, Amardeep S. G. Kolbitsch, Christoph Schmoll, Tilman Leitgeb, Rainer A. |
author_sort | Singh, Amardeep S. G. |
collection | PubMed |
description | Doppler optical coherence tomography has the capability to measure blood flow quantitatively and in vivo. As only the axial component of the velocity can be assessed, the measurements have to be corrected for the angle of the vessels. We present a novel approach to extract quantitative flow data from circumpapillary scans in vivo on the human retina by registering the circular scan to a reference volume scan and extracting the angle directly from the volume. In addition, we perform phase unwrapping and interpolation of the flow under the assumption of a parabolic flow profile. We demonstrate the repeatability of the methods by applying it to different retinal vessels, achieving coefficients of variation of the average velocity of 3 to 8%. Results on the pulsatility and resistance index are also presented. |
format | Text |
id | pubmed-3018083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-30180832011-01-21 Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans Singh, Amardeep S. G. Kolbitsch, Christoph Schmoll, Tilman Leitgeb, Rainer A. Biomed Opt Express Optical Coherence Tomography Doppler optical coherence tomography has the capability to measure blood flow quantitatively and in vivo. As only the axial component of the velocity can be assessed, the measurements have to be corrected for the angle of the vessels. We present a novel approach to extract quantitative flow data from circumpapillary scans in vivo on the human retina by registering the circular scan to a reference volume scan and extracting the angle directly from the volume. In addition, we perform phase unwrapping and interpolation of the flow under the assumption of a parabolic flow profile. We demonstrate the repeatability of the methods by applying it to different retinal vessels, achieving coefficients of variation of the average velocity of 3 to 8%. Results on the pulsatility and resistance index are also presented. Optical Society of America 2010-10-01 /pmc/articles/PMC3018083/ /pubmed/21258529 http://dx.doi.org/10.1364/BOE.1.001047 Text en ©2010 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially. |
spellingShingle | Optical Coherence Tomography Singh, Amardeep S. G. Kolbitsch, Christoph Schmoll, Tilman Leitgeb, Rainer A. Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans |
title | Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans |
title_full | Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans |
title_fullStr | Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans |
title_full_unstemmed | Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans |
title_short | Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans |
title_sort | stable absolute flow estimation with doppler oct based on virtual circumpapillary scans |
topic | Optical Coherence Tomography |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018083/ https://www.ncbi.nlm.nih.gov/pubmed/21258529 http://dx.doi.org/10.1364/BOE.1.001047 |
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