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Collagen cross-linking with riboflavin and ultraviolet-A light in keratoconus: One-year results

BACKGROUND: The aim of this study is to evaluate the safety and effectiveness of riboflavin-ultraviolet type A (UV-A) light rays induced cross-linking of corneal collagen in improving visual acuity and in stabilizing the progression of keratoconic eyes. The method of corneal cross-linking using ribo...

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Autores principales: Arbelaez, Maria Clara, Sekito, Maria Bernardita, Vidal, Camila, Choudhury, Sanak Roy
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018104/
https://www.ncbi.nlm.nih.gov/pubmed/21234222
http://dx.doi.org/10.4103/0974-620X.48420
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author Arbelaez, Maria Clara
Sekito, Maria Bernardita
Vidal, Camila
Choudhury, Sanak Roy
author_facet Arbelaez, Maria Clara
Sekito, Maria Bernardita
Vidal, Camila
Choudhury, Sanak Roy
author_sort Arbelaez, Maria Clara
collection PubMed
description BACKGROUND: The aim of this study is to evaluate the safety and effectiveness of riboflavin-ultraviolet type A (UV-A) light rays induced cross-linking of corneal collagen in improving visual acuity and in stabilizing the progression of keratoconic eyes. The method of corneal cross-linking using riboflavin and UV-A light is technically simple and less invasive than all other therapies proposed for keratoconus. It is the only treatment that treats not only the refractive effects of the condition but the underlying pathophysiology. MATERIALS AND METHODS: In this prospective, nonrandomized clinical study, 20 eyes of 19 patients with keratoconus were treated by combined riboflavin UV-A collagen cross linking. The eyes were saturated with riboflavin solution and were subjected for 30 min under UV-A light with a dose parameter of 3 mW/cm(2). Safety and effectiveness of the treatment was assessed by measuring the uncorrected visual acuity, best corrected visual acuity, manifest cylinder/sphere, keratometry, pachymetry, posterior and anterior elevations from Pentacam and corneal aberrations at 6 months and 1 year post-treatment. RESULTS: Comparative analysis of the pre-operative and 1 year post-operative evaluation showed a mean gain of 4.15 lines of UCVA (P= 0.001) and 1.65 lines of BCVA (P= 0.002). The reduction in the average keratometry reading was 1.36 D (P= 0.0004) and 1.4 D (P= 0.001) at the apex. Manifest refraction sphere showed a mean reduction of 1.26 D (P= 0.033) and 1.25 D (0.0003) for manifest cylinder. Topo-aberrometric analysis showed improvement in corneal symmetry. CONCLUSION: Cross-linking was safe and an effective therapeutical option for progressive keratoconus.
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spelling pubmed-30181042011-01-13 Collagen cross-linking with riboflavin and ultraviolet-A light in keratoconus: One-year results Arbelaez, Maria Clara Sekito, Maria Bernardita Vidal, Camila Choudhury, Sanak Roy Oman J Ophthalmol Original Article BACKGROUND: The aim of this study is to evaluate the safety and effectiveness of riboflavin-ultraviolet type A (UV-A) light rays induced cross-linking of corneal collagen in improving visual acuity and in stabilizing the progression of keratoconic eyes. The method of corneal cross-linking using riboflavin and UV-A light is technically simple and less invasive than all other therapies proposed for keratoconus. It is the only treatment that treats not only the refractive effects of the condition but the underlying pathophysiology. MATERIALS AND METHODS: In this prospective, nonrandomized clinical study, 20 eyes of 19 patients with keratoconus were treated by combined riboflavin UV-A collagen cross linking. The eyes were saturated with riboflavin solution and were subjected for 30 min under UV-A light with a dose parameter of 3 mW/cm(2). Safety and effectiveness of the treatment was assessed by measuring the uncorrected visual acuity, best corrected visual acuity, manifest cylinder/sphere, keratometry, pachymetry, posterior and anterior elevations from Pentacam and corneal aberrations at 6 months and 1 year post-treatment. RESULTS: Comparative analysis of the pre-operative and 1 year post-operative evaluation showed a mean gain of 4.15 lines of UCVA (P= 0.001) and 1.65 lines of BCVA (P= 0.002). The reduction in the average keratometry reading was 1.36 D (P= 0.0004) and 1.4 D (P= 0.001) at the apex. Manifest refraction sphere showed a mean reduction of 1.26 D (P= 0.033) and 1.25 D (0.0003) for manifest cylinder. Topo-aberrometric analysis showed improvement in corneal symmetry. CONCLUSION: Cross-linking was safe and an effective therapeutical option for progressive keratoconus. Medknow Publications 2009 /pmc/articles/PMC3018104/ /pubmed/21234222 http://dx.doi.org/10.4103/0974-620X.48420 Text en © Oman Journal of Ophthalmology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Arbelaez, Maria Clara
Sekito, Maria Bernardita
Vidal, Camila
Choudhury, Sanak Roy
Collagen cross-linking with riboflavin and ultraviolet-A light in keratoconus: One-year results
title Collagen cross-linking with riboflavin and ultraviolet-A light in keratoconus: One-year results
title_full Collagen cross-linking with riboflavin and ultraviolet-A light in keratoconus: One-year results
title_fullStr Collagen cross-linking with riboflavin and ultraviolet-A light in keratoconus: One-year results
title_full_unstemmed Collagen cross-linking with riboflavin and ultraviolet-A light in keratoconus: One-year results
title_short Collagen cross-linking with riboflavin and ultraviolet-A light in keratoconus: One-year results
title_sort collagen cross-linking with riboflavin and ultraviolet-a light in keratoconus: one-year results
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018104/
https://www.ncbi.nlm.nih.gov/pubmed/21234222
http://dx.doi.org/10.4103/0974-620X.48420
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