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Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation

Nonsense-mediated mRNA decay (NMD) is a surveillance system that eliminates transcripts with premature termination codons. In this study, we show that mRNAs targeted by NMD are also suppressed at the translational level. The low translational efficiency (TE) is a consequence of multiple features act...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhenguo, Zhou, Li, Hu, Landian, Zhu, Yufei, Xu, Heng, Liu, Yang, Chen, Xianfen, Yi, Xianfu, Kong, Xiangyin, Hurst, Laurence D
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2010
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018160/ https://www.ncbi.nlm.nih.gov/pubmed/21179015 http://dx.doi.org/10.1038/msb.2010.101

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