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Evolving a robust signal transduction pathway from weak cross-talk

We have evolved a robust two-component signal transduction pathway from a sensor kinase (SK) and non-partner response regulator (RR) that show weak cross-talk in vitro and no detectable cross-talk in vivo in wild-type strains. The SK, CpxA, is bifunctional, with both kinase and phosphatase activitie...

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Detalles Bibliográficos
Autores principales:	Siryaporn, Albert, Perchuk, Barrett S, Laub, Michael T, Goulian, Mark
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2010
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018164/ https://www.ncbi.nlm.nih.gov/pubmed/21179024 http://dx.doi.org/10.1038/msb.2010.105

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