Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action

We present a cross-species chemogenomic screening platform using libraries of haploid deletion mutants from two yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe. We screened a set of compounds of known and unknown mode of action (MoA) and derived quantitative drug scores (or D-s...

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Detalles Bibliográficos
Autores principales: Kapitzky, Laura, Beltrao, Pedro, Berens, Theresa J, Gassner, Nadine, Zhou, Chunshui, Wüster, Arthur, Wu, Julie, Babu, M Madan, Elledge, Stephen J, Toczyski, David, Lokey, R Scott, Krogan, Nevan J
Formato: Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018166/
https://www.ncbi.nlm.nih.gov/pubmed/21179023
http://dx.doi.org/10.1038/msb.2010.107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018166/
https://www.ncbi.nlm.nih.gov/pubmed/21179023
http://dx.doi.org/10.1038/msb.2010.107

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