Vital Rates from the Action of Mutation Accumulation

New models for evolutionary processes of mutation accumulation allow hypotheses about the age-specificity of mutational effects to be translated into predictions of heterogeneous population hazard functions. We apply these models to questions in the biodemography of longevity, including proposed exp...

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Detalles Bibliográficos
Autores principales: Wachter, Kenneth W., Steinsaltz, David R., Evans, Steven N.
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018262/
https://www.ncbi.nlm.nih.gov/pubmed/21258638
http://dx.doi.org/10.1007/s12062-009-9015-3
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author Wachter, Kenneth W.
Steinsaltz, David R.
Evans, Steven N.
author_facet Wachter, Kenneth W.
Steinsaltz, David R.
Evans, Steven N.
author_sort Wachter, Kenneth W.
collection PubMed
description New models for evolutionary processes of mutation accumulation allow hypotheses about the age-specificity of mutational effects to be translated into predictions of heterogeneous population hazard functions. We apply these models to questions in the biodemography of longevity, including proposed explanations of Gompertz hazards and mortality plateaus.
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spelling pubmed-30182622011-01-19 Vital Rates from the Action of Mutation Accumulation Wachter, Kenneth W. Steinsaltz, David R. Evans, Steven N. J Popul Ageing Article New models for evolutionary processes of mutation accumulation allow hypotheses about the age-specificity of mutational effects to be translated into predictions of heterogeneous population hazard functions. We apply these models to questions in the biodemography of longevity, including proposed explanations of Gompertz hazards and mortality plateaus. Springer Netherlands 2010-01-01 2010 /pmc/articles/PMC3018262/ /pubmed/21258638 http://dx.doi.org/10.1007/s12062-009-9015-3 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Wachter, Kenneth W.
Steinsaltz, David R.
Evans, Steven N.
Vital Rates from the Action of Mutation Accumulation
title Vital Rates from the Action of Mutation Accumulation
title_full Vital Rates from the Action of Mutation Accumulation
title_fullStr Vital Rates from the Action of Mutation Accumulation
title_full_unstemmed Vital Rates from the Action of Mutation Accumulation
title_short Vital Rates from the Action of Mutation Accumulation
title_sort vital rates from the action of mutation accumulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018262/
https://www.ncbi.nlm.nih.gov/pubmed/21258638
http://dx.doi.org/10.1007/s12062-009-9015-3
work_keys_str_mv AT wachterkennethw vitalratesfromtheactionofmutationaccumulation
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AT evansstevenn vitalratesfromtheactionofmutationaccumulation

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