Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors

BACKGROUND: The mutation in Huntington's disease is a polyglutamine expansion near the N-terminus of huntingtin. Huntingtin expressed in immortalized neurons is cleaved near the N-terminus to form N-terminal polypeptides known as cleavage products A and B (cpA and cpB). CpA and cpB with polyglu...

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Detalles Bibliográficos
Autores principales: Kegel, Kimberly B, Sapp, Ellen, Alexander, Jonathan, Reeves, Patrick, Bleckmann, Dorothee, Sobin, Linsday, Masso, Nicholas, Valencia, Antonio, Jeong, Hyunkyung, Krainc, Dimitri, Palacino, James, Curtis, Daniel, Kuhn, Rainer, Betschart, Claudia, Sena-Esteves, Miguel, Aronin, Neil, Paganetti, Paolo, DiFiglia, Marian
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018386/
https://www.ncbi.nlm.nih.gov/pubmed/21156064
http://dx.doi.org/10.1186/1750-1326-5-58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018386/
https://www.ncbi.nlm.nih.gov/pubmed/21156064
http://dx.doi.org/10.1186/1750-1326-5-58

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