The checkpointkinase 2 (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN)

BACKGROUND: The checkpointkinase 2 (CHK2) is part of the highly conserved ATM-CHK2 signaling pathway, which is activated in response to DNA damage, in particular after double strand breaks which can be caused by carcinogens like smoking. After induction of downstream targets, e.g. the tumor suppress...

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Detalles Bibliográficos
Autores principales: Scheckenbach, Kathrin, Papadopoulou, Galatia, Hoffmann, Thomas K, Chaker, Adam, Bier, Henning, Schipper, Jörg, Balz, Vera, Wagenmann, Martin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018459/
https://www.ncbi.nlm.nih.gov/pubmed/21184685
http://dx.doi.org/10.1186/1477-5751-9-10

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