High- and Low-Affinity Epidermal Growth Factor Receptor-Ligand Interactions Activate Distinct Signaling Pathways

Signaling mediated by the Epidermal Growth Factor Receptor (EGFR) is crucial in normal development, and aberrant EGFR signaling has been implicated in a wide variety of cancers. Here we find that the high- and low-affinity interactions between EGFR and its ligands activate different signaling pathwa...

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Detalles Bibliográficos
Autores principales: Krall, Jordan A., Beyer, Elsa M., MacBeath, Gavin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018525/
https://www.ncbi.nlm.nih.gov/pubmed/21264347
http://dx.doi.org/10.1371/journal.pone.0015945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018525/
https://www.ncbi.nlm.nih.gov/pubmed/21264347
http://dx.doi.org/10.1371/journal.pone.0015945

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