Impact of HPV in Oropharyngeal Cancer

The incidence of oropharyngeal cancers has increased in the western world and Human Papilloma Virus (HPV) has been recognised as a risk factor in the last decades. During the same period the prevalence of HPV in oropharyngeal tumours has increased and HPV has been suggested responsible for the incre...

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Detalles Bibliográficos
Autores principales: Marklund, Linda, Hammarstedt, Lalle
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018627/
https://www.ncbi.nlm.nih.gov/pubmed/21234307
http://dx.doi.org/10.1155/2011/509036
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author Marklund, Linda
Hammarstedt, Lalle
author_facet Marklund, Linda
Hammarstedt, Lalle
author_sort Marklund, Linda
collection PubMed
description The incidence of oropharyngeal cancers has increased in the western world and Human Papilloma Virus (HPV) has been recognised as a risk factor in the last decades. During the same period the prevalence of HPV in oropharyngeal tumours has increased and HPV has been suggested responsible for the increase. The HPV-positive tumours are today recognized as a distinct subset of head and neck cancers with its own clinopathological and risk profile and have a significantly improved prognosis regardless of treatment strategy. This review summarizes current knowledge regarding human papillomavirus biology, oncogenic mechanisms, risk factors, and impact of treatment.
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spelling pubmed-30186272011-01-13 Impact of HPV in Oropharyngeal Cancer Marklund, Linda Hammarstedt, Lalle J Oncol Review Article The incidence of oropharyngeal cancers has increased in the western world and Human Papilloma Virus (HPV) has been recognised as a risk factor in the last decades. During the same period the prevalence of HPV in oropharyngeal tumours has increased and HPV has been suggested responsible for the increase. The HPV-positive tumours are today recognized as a distinct subset of head and neck cancers with its own clinopathological and risk profile and have a significantly improved prognosis regardless of treatment strategy. This review summarizes current knowledge regarding human papillomavirus biology, oncogenic mechanisms, risk factors, and impact of treatment. Hindawi Publishing Corporation 2011 2010-12-29 /pmc/articles/PMC3018627/ /pubmed/21234307 http://dx.doi.org/10.1155/2011/509036 Text en Copyright © 2011 L. Marklund and L. Hammarstedt. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Marklund, Linda
Hammarstedt, Lalle
Impact of HPV in Oropharyngeal Cancer
title Impact of HPV in Oropharyngeal Cancer
title_full Impact of HPV in Oropharyngeal Cancer
title_fullStr Impact of HPV in Oropharyngeal Cancer
title_full_unstemmed Impact of HPV in Oropharyngeal Cancer
title_short Impact of HPV in Oropharyngeal Cancer
title_sort impact of hpv in oropharyngeal cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018627/
https://www.ncbi.nlm.nih.gov/pubmed/21234307
http://dx.doi.org/10.1155/2011/509036
work_keys_str_mv AT marklundlinda impactofhpvinoropharyngealcancer
AT hammarstedtlalle impactofhpvinoropharyngealcancer

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