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Relationship between Fibroblast Growth Factor-23 and Mineral Metabolism in Chronic Kidney Disease
Fibroblast growth factor- (FGF-)23 is a recently discovered regulator of calcium-phosphate metabolism. FGF-23 appears to decrease in synthesis and accelerated degradation of 1,25(OH)(2)D. Together with its cofactor Klotho, FGF-23 maintains serum phosphate levels within the normal range by increasing...
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Formato: | Texto |
Lenguaje: | English |
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SAGE-Hindawi Access to Research
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018630/ https://www.ncbi.nlm.nih.gov/pubmed/21234310 http://dx.doi.org/10.4061/2010/167984 |
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author | Nitta, Kosaku |
author_facet | Nitta, Kosaku |
author_sort | Nitta, Kosaku |
collection | PubMed |
description | Fibroblast growth factor- (FGF-)23 is a recently discovered regulator of calcium-phosphate metabolism. FGF-23 appears to decrease in synthesis and accelerated degradation of 1,25(OH)(2)D. Together with its cofactor Klotho, FGF-23 maintains serum phosphate levels within the normal range by increasing renal phosphate excretion. In chronic kidney disease (CKD), FGF-23 levels rise in parallel with the decline in renal function long before a significant increase in serum phosphate concentration occurs. Both Klotho and FGF-23, linked by a receptor mechanism, affect vitamin D synthesis and parathyroid hormone (PTH) secretion. Previous studies have shown a close association between reduced FGF-23 or Klotho activities and vascular calcification. The possible association of FGF-23 and left ventricular hypertrophy or vascular dysfunction has been proposed. Finally, prospective studies have shown that high serum FGF-23 concentrations predict more rapid disease progression in CKD patients who were not on dialysis and increased mortality in patients on maintenance hemodialysis. FGF-23 may therefore prove to be an important therapeutic target for the management of CKD. |
format | Text |
id | pubmed-3018630 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-30186302011-01-13 Relationship between Fibroblast Growth Factor-23 and Mineral Metabolism in Chronic Kidney Disease Nitta, Kosaku Int J Nephrol Review Article Fibroblast growth factor- (FGF-)23 is a recently discovered regulator of calcium-phosphate metabolism. FGF-23 appears to decrease in synthesis and accelerated degradation of 1,25(OH)(2)D. Together with its cofactor Klotho, FGF-23 maintains serum phosphate levels within the normal range by increasing renal phosphate excretion. In chronic kidney disease (CKD), FGF-23 levels rise in parallel with the decline in renal function long before a significant increase in serum phosphate concentration occurs. Both Klotho and FGF-23, linked by a receptor mechanism, affect vitamin D synthesis and parathyroid hormone (PTH) secretion. Previous studies have shown a close association between reduced FGF-23 or Klotho activities and vascular calcification. The possible association of FGF-23 and left ventricular hypertrophy or vascular dysfunction has been proposed. Finally, prospective studies have shown that high serum FGF-23 concentrations predict more rapid disease progression in CKD patients who were not on dialysis and increased mortality in patients on maintenance hemodialysis. FGF-23 may therefore prove to be an important therapeutic target for the management of CKD. SAGE-Hindawi Access to Research 2010-12-30 /pmc/articles/PMC3018630/ /pubmed/21234310 http://dx.doi.org/10.4061/2010/167984 Text en Copyright © 2010 Kosaku Nitta. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Nitta, Kosaku Relationship between Fibroblast Growth Factor-23 and Mineral Metabolism in Chronic Kidney Disease |
title | Relationship between Fibroblast Growth Factor-23 and Mineral Metabolism in Chronic Kidney Disease |
title_full | Relationship between Fibroblast Growth Factor-23 and Mineral Metabolism in Chronic Kidney Disease |
title_fullStr | Relationship between Fibroblast Growth Factor-23 and Mineral Metabolism in Chronic Kidney Disease |
title_full_unstemmed | Relationship between Fibroblast Growth Factor-23 and Mineral Metabolism in Chronic Kidney Disease |
title_short | Relationship between Fibroblast Growth Factor-23 and Mineral Metabolism in Chronic Kidney Disease |
title_sort | relationship between fibroblast growth factor-23 and mineral metabolism in chronic kidney disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018630/ https://www.ncbi.nlm.nih.gov/pubmed/21234310 http://dx.doi.org/10.4061/2010/167984 |
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