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Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract
There is evidence that the principles present in the widely consumed Indian food plant C. fimbriata extract (CFE) suppress appetite, and provide antiobesogenic and metabolic benefits. The Diet-Induced Obesity (DIO) rat model was used to investigate CFE's anorexigenic effects. Rats were randomly...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018644/ https://www.ncbi.nlm.nih.gov/pubmed/21234320 http://dx.doi.org/10.1155/2010/285301 |
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author | Kamalakkannan, Soundararajan Rajendran, Ramaswamy Venkatesh, Ramasamy V. Clayton, Paul Akbarsha, Mohammad A. |
author_facet | Kamalakkannan, Soundararajan Rajendran, Ramaswamy Venkatesh, Ramasamy V. Clayton, Paul Akbarsha, Mohammad A. |
author_sort | Kamalakkannan, Soundararajan |
collection | PubMed |
description | There is evidence that the principles present in the widely consumed Indian food plant C. fimbriata extract (CFE) suppress appetite, and provide antiobesogenic and metabolic benefits. The Diet-Induced Obesity (DIO) rat model was used to investigate CFE's anorexigenic effects. Rats were randomly divided into three groups: (i) untreated control (C), (ii) control for cafeteria diet (CA), and (iii) cafeteria diet fed + CFE treated. Rats in the test group received cafeteria diet and CFE from day one onwards. CFE was administered by gavage at three doses (25, 50, 100 mg/Kg BW per day) for 90 days. The antiobesogenic effects of CFE were evaluated by monitoring changes in feed intake, body weight, serum lipid and hormonal (leptin) profiles, fat pads, and liver weight. Antiatherosclerotic effects were measured by histology. CFE induced significant and dose-dependent inhibition of food intake, with dose-related prevention of gains in body weight, liver weight, and fat pad mass. Alterations in serum lipid profiles associated with weight gain were similarly inhibited, as were the typical increases in serum leptin levels. These data substantiate CFE's reported anorexigenic effects. CFE treatment also conferred protection against atherogenesis. We conclude that CFE possesses antiobesogenic and antiatherosclerotic properties. |
format | Text |
id | pubmed-3018644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30186442011-01-13 Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract Kamalakkannan, Soundararajan Rajendran, Ramaswamy Venkatesh, Ramasamy V. Clayton, Paul Akbarsha, Mohammad A. J Nutr Metab Research Article There is evidence that the principles present in the widely consumed Indian food plant C. fimbriata extract (CFE) suppress appetite, and provide antiobesogenic and metabolic benefits. The Diet-Induced Obesity (DIO) rat model was used to investigate CFE's anorexigenic effects. Rats were randomly divided into three groups: (i) untreated control (C), (ii) control for cafeteria diet (CA), and (iii) cafeteria diet fed + CFE treated. Rats in the test group received cafeteria diet and CFE from day one onwards. CFE was administered by gavage at three doses (25, 50, 100 mg/Kg BW per day) for 90 days. The antiobesogenic effects of CFE were evaluated by monitoring changes in feed intake, body weight, serum lipid and hormonal (leptin) profiles, fat pads, and liver weight. Antiatherosclerotic effects were measured by histology. CFE induced significant and dose-dependent inhibition of food intake, with dose-related prevention of gains in body weight, liver weight, and fat pad mass. Alterations in serum lipid profiles associated with weight gain were similarly inhibited, as were the typical increases in serum leptin levels. These data substantiate CFE's reported anorexigenic effects. CFE treatment also conferred protection against atherogenesis. We conclude that CFE possesses antiobesogenic and antiatherosclerotic properties. Hindawi Publishing Corporation 2010 2010-12-28 /pmc/articles/PMC3018644/ /pubmed/21234320 http://dx.doi.org/10.1155/2010/285301 Text en Copyright © 2010 Soundararajan Kamalakkannan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kamalakkannan, Soundararajan Rajendran, Ramaswamy Venkatesh, Ramasamy V. Clayton, Paul Akbarsha, Mohammad A. Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract |
title | Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract |
title_full | Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract |
title_fullStr | Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract |
title_full_unstemmed | Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract |
title_short | Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract |
title_sort | antiobesogenic and antiatherosclerotic properties of caralluma fimbriata extract |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018644/ https://www.ncbi.nlm.nih.gov/pubmed/21234320 http://dx.doi.org/10.1155/2010/285301 |
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