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Rodent Models for Metabolic Syndrome Research
Rodents are widely used to mimic human diseases to improve understanding of the causes and progression of disease symptoms and to test potential therapeutic interventions. Chronic diseases such as obesity, diabetes and hypertension, together known as the metabolic syndrome, are causing increasing mo...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018657/ https://www.ncbi.nlm.nih.gov/pubmed/21253582 http://dx.doi.org/10.1155/2011/351982 |
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author | Panchal, Sunil K. Brown, Lindsay |
author_facet | Panchal, Sunil K. Brown, Lindsay |
author_sort | Panchal, Sunil K. |
collection | PubMed |
description | Rodents are widely used to mimic human diseases to improve understanding of the causes and progression of disease symptoms and to test potential therapeutic interventions. Chronic diseases such as obesity, diabetes and hypertension, together known as the metabolic syndrome, are causing increasing morbidity and mortality. To control these diseases, research in rodent models that closely mimic the changes in humans is essential. This review will examine the adequacy of the many rodent models of metabolic syndrome to mimic the causes and progression of the disease in humans. The primary criterion will be whether a rodent model initiates all of the signs, especially obesity, diabetes, hypertension and dysfunction of the heart, blood vessels, liver and kidney, primarily by diet since these are the diet-induced signs in humans with metabolic syndrome. We conclude that the model that comes closest to fulfilling this criterion is the high carbohydrate, high fat-fed male rodent. |
format | Text |
id | pubmed-3018657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30186572011-01-20 Rodent Models for Metabolic Syndrome Research Panchal, Sunil K. Brown, Lindsay J Biomed Biotechnol Review Article Rodents are widely used to mimic human diseases to improve understanding of the causes and progression of disease symptoms and to test potential therapeutic interventions. Chronic diseases such as obesity, diabetes and hypertension, together known as the metabolic syndrome, are causing increasing morbidity and mortality. To control these diseases, research in rodent models that closely mimic the changes in humans is essential. This review will examine the adequacy of the many rodent models of metabolic syndrome to mimic the causes and progression of the disease in humans. The primary criterion will be whether a rodent model initiates all of the signs, especially obesity, diabetes, hypertension and dysfunction of the heart, blood vessels, liver and kidney, primarily by diet since these are the diet-induced signs in humans with metabolic syndrome. We conclude that the model that comes closest to fulfilling this criterion is the high carbohydrate, high fat-fed male rodent. Hindawi Publishing Corporation 2011 2010-12-30 /pmc/articles/PMC3018657/ /pubmed/21253582 http://dx.doi.org/10.1155/2011/351982 Text en Copyright © 2011 S. K. Panchal and L. Brown. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Panchal, Sunil K. Brown, Lindsay Rodent Models for Metabolic Syndrome Research |
title | Rodent Models for Metabolic Syndrome Research |
title_full | Rodent Models for Metabolic Syndrome Research |
title_fullStr | Rodent Models for Metabolic Syndrome Research |
title_full_unstemmed | Rodent Models for Metabolic Syndrome Research |
title_short | Rodent Models for Metabolic Syndrome Research |
title_sort | rodent models for metabolic syndrome research |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018657/ https://www.ncbi.nlm.nih.gov/pubmed/21253582 http://dx.doi.org/10.1155/2011/351982 |
work_keys_str_mv | AT panchalsunilk rodentmodelsformetabolicsyndromeresearch AT brownlindsay rodentmodelsformetabolicsyndromeresearch |