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DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging

During the last decades, our knowledge about the processes involved in the aging process has exponentially increased. However, further investigation will be still required to globally understand the complexity of aging. Aging is a multifactorial phenomenon characterized by increased susceptibility t...

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Autor principal: Gredilla, Ricardo
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018712/
https://www.ncbi.nlm.nih.gov/pubmed/21234332
http://dx.doi.org/10.4061/2011/257093
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author Gredilla, Ricardo
author_facet Gredilla, Ricardo
author_sort Gredilla, Ricardo
collection PubMed
description During the last decades, our knowledge about the processes involved in the aging process has exponentially increased. However, further investigation will be still required to globally understand the complexity of aging. Aging is a multifactorial phenomenon characterized by increased susceptibility to cellular loss and functional decline, where mitochondrial DNA mutations and mitochondrial DNA damage response are thought to play important roles. Due to the proximity of mitochondrial DNA to the main sites of mitochondrial-free radical generation, oxidative stress is a major source of mitochondrial DNA mutations. Mitochondrial DNA repair mechanisms, in particular the base excision repair pathway, constitute an important mechanism for maintenance of mitochondrial DNA integrity. The results reviewed here support that mitochondrial DNA damage plays an important role in aging.
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spelling pubmed-30187122011-01-13 DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging Gredilla, Ricardo J Aging Res Review Article During the last decades, our knowledge about the processes involved in the aging process has exponentially increased. However, further investigation will be still required to globally understand the complexity of aging. Aging is a multifactorial phenomenon characterized by increased susceptibility to cellular loss and functional decline, where mitochondrial DNA mutations and mitochondrial DNA damage response are thought to play important roles. Due to the proximity of mitochondrial DNA to the main sites of mitochondrial-free radical generation, oxidative stress is a major source of mitochondrial DNA mutations. Mitochondrial DNA repair mechanisms, in particular the base excision repair pathway, constitute an important mechanism for maintenance of mitochondrial DNA integrity. The results reviewed here support that mitochondrial DNA damage plays an important role in aging. SAGE-Hindawi Access to Research 2010-12-30 /pmc/articles/PMC3018712/ /pubmed/21234332 http://dx.doi.org/10.4061/2011/257093 Text en Copyright © 2011 Ricardo Gredilla. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gredilla, Ricardo
DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging
title DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging
title_full DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging
title_fullStr DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging
title_full_unstemmed DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging
title_short DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging
title_sort dna damage and base excision repair in mitochondria and their role in aging
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018712/
https://www.ncbi.nlm.nih.gov/pubmed/21234332
http://dx.doi.org/10.4061/2011/257093
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