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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Circulating glucose levels are tightly regulated. To identify novel glycemic loci, we performed meta-analyses of 21 genome-wide associations studies informative for fasting glucose (FG), fasting insulin (FI) and indices of β-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 non...
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018764/ https://www.ncbi.nlm.nih.gov/pubmed/20081858 http://dx.doi.org/10.1038/ng.520 |
| _version_ | 1782196118493331456 |
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| author | Dupuis, Josée Langenberg, Claudia Prokopenko, Inga Saxena, Richa Soranzo, Nicole Jackson, Anne U Wheeler, Eleanor Glazer, Nicole L Bouatia-Naji, Nabila Gloyn, Anna L Lindgren, Cecilia M Mägi, Reedik Morris, Andrew P Randall, Joshua Johnson, Toby Elliott, Paul Rybin, Denis Thorleifsson, Gudmar Steinthorsdottir, Valgerdur Henneman, Peter Grallert, Harald Dehghan, Abbas Hottenga, Jouke Jan Franklin, Christopher S Navarro, Pau Song, Kijoung Goel, Anuj Perry, John R B Egan, Josephine M Lajunen, Taina Grarup, Niels Sparsø, Thomas Doney, Alex Voight, Benjamin F Stringham, Heather M Li, Man Kanoni, Stavroula Shrader, Peter Cavalcanti-Proença, Christine Kumari, Meena Qi, Lu Timpson, Nicholas J Gieger, Christian Zabena, Carina Rocheleau, Ghislain Ingelsson, Erik An, Ping O’Connell, Jeffrey Luan, Jian'an Elliott, Amanda McCarroll, Steven A Payne, Felicity Roccasecca, Rosa Maria Pattou, François Sethupathy, Praveen Ardlie, Kristin Ariyurek, Yavuz Balkau, Beverley Barter, Philip Beilby, John P Ben-Shlomo, Yoav Benediktsson, Rafn Bennett, Amanda J Bergmann, Sven Bochud, Murielle Boerwinkle, Eric Bonnefond, Amélie Bonnycastle, Lori L Borch-Johnsen, Knut Böttcher, Yvonne Brunner, Eric Bumpstead, Suzannah J Charpentier, Guillaume Chen, Yii-Der Ida Chines, Peter Clarke, Robert Coin, Lachlan J M Cooper, Matthew N Cornelis, Marilyn Crawford, Gabe Crisponi, Laura Day, Ian N M de Geus, Eco Delplanque, Jerome Dina, Christian Erdos, Michael R Fedson, Annette C Fischer-Rosinsky, Antje Forouhi, Nita G Fox, Caroline S Frants, Rune Franzosi, Maria Grazia Galan, Pilar Goodarzi, Mark O Graessler, Jürgen Groves, Christopher J Grundy, Scott Gwilliam, Rhian Gyllensten, Ulf Hadjadj, Samy Hallmans, Göran Hammond, Naomi Han, Xijing Hartikainen, Anna-Liisa Hassanali, Neelam Hayward, Caroline Heath, Simon C Hercberg, Serge Herder, Christian Hicks, Andrew A Hillman, David R Hingorani, Aroon D Hofman, Albert Hui, Jennie Hung, Joe Isomaa, Bo Johnson, Paul R V Jørgensen, Torben Jula, Antti Kaakinen, Marika Kaprio, Jaakko Kesaniemi, Y Antero Kivimaki, Mika Knight, Beatrice Koskinen, Seppo Kovacs, Peter Kyvik, Kirsten Ohm Lathrop, G Mark Lawlor, Debbie A Le Bacquer, Olivier Lecoeur, Cécile Li, Yun Lyssenko, Valeriya Mahley, Robert Mangino, Massimo Manning, Alisa K Martínez-Larrad, María Teresa McAteer, Jarred B McCulloch, Laura J McPherson, Ruth Meisinger, Christa Melzer, David Meyre, David Mitchell, Braxton D Morken, Mario A Mukherjee, Sutapa Naitza, Silvia Narisu, Narisu Neville, Matthew J Oostra, Ben A Orrù, Marco Pakyz, Ruth Palmer, Colin N A Paolisso, Giuseppe Pattaro, Cristian Pearson, Daniel Peden, John F Pedersen, Nancy L. Perola, Markus Pfeiffer, Andreas F H Pichler, Irene Polasek, Ozren Posthuma, Danielle Potter, Simon C Pouta, Anneli Province, Michael A Psaty, Bruce M Rathmann, Wolfgang Rayner, Nigel W Rice, Kenneth Ripatti, Samuli Rivadeneira, Fernando Roden, Michael Rolandsson, Olov Sandbaek, Annelli Sandhu, Manjinder Sanna, Serena Sayer, Avan Aihie Scheet, Paul Scott, Laura J Seedorf, Udo Sharp, Stephen J Shields, Beverley Sigurðsson, Gunnar Sijbrands, Erik J G Silveira, Angela Simpson, Laila Singleton, Andrew Smith, Nicholas L Sovio, Ulla Swift, Amy Syddall, Holly Syvänen, Ann-Christine Tanaka, Toshiko Thorand, Barbara Tichet, Jean Tönjes, Anke Tuomi, Tiinamaija Uitterlinden, André G van Dijk, Ko Willems van Hoek, Mandy Varma, Dhiraj Visvikis-Siest, Sophie Vitart, Veronique Vogelzangs, Nicole Waeber, Gérard Wagner, Peter J Walley, Andrew Walters, G Bragi Ward, Kim L Watkins, Hugh Weedon, Michael N Wild, Sarah H Willemsen, Gonneke Witteman, Jaqueline C M Yarnell, John W G Zeggini, Eleftheria Zelenika, Diana Zethelius, Björn Zhai, Guangju Zhao, Jing Hua Zillikens, M Carola Borecki, Ingrid B Loos, Ruth J F Meneton, Pierre Magnusson, Patrik K E Nathan, David M Williams, Gordon H Hattersley, Andrew T Silander, Kaisa Salomaa, Veikko Smith, George Davey Bornstein, Stefan R Schwarz, Peter Spranger, Joachim Karpe, Fredrik Shuldiner, Alan R Cooper, Cyrus Dedoussis, George V Serrano-Ríos, Manuel Morris, Andrew D Lind, Lars Palmer, Lyle J Hu, Frank B. Franks, Paul W Ebrahim, Shah Marmot, Michael Kao, W H Linda Pankow, James S Sampson, Michael J Kuusisto, Johanna Laakso, Markku Hansen, Torben Pedersen, Oluf Pramstaller, Peter Paul Wichmann, H Erich Illig, Thomas Rudan, Igor Wright, Alan F Stumvoll, Michael Campbell, Harry Wilson, James F Hamsten, Anders Bergman, Richard N Buchanan, Thomas A Collins, Francis S Mohlke, Karen L Tuomilehto, Jaakko Valle, Timo T Altshuler, David Rotter, Jerome I Siscovick, David S Penninx, Brenda W J H Boomsma, Dorret Deloukas, Panos Spector, Timothy D Frayling, Timothy M Ferrucci, Luigi Kong, Augustine Thorsteinsdottir, Unnur Stefansson, Kari van Duijn, Cornelia M Aulchenko, Yurii S Cao, Antonio Scuteri, Angelo Schlessinger, David Uda, Manuela Ruokonen, Aimo Jarvelin, Marjo-Riitta Waterworth, Dawn M Vollenweider, Peter Peltonen, Leena Mooser, Vincent Abecasis, Goncalo R Wareham, Nicholas J Sladek, Robert Froguel, Philippe Watanabe, Richard M Meigs, James B Groop, Leif Boehnke, Michael McCarthy, Mark I Florez, Jose C Barroso, Inês |
| author_facet | Dupuis, Josée Langenberg, Claudia Prokopenko, Inga Saxena, Richa Soranzo, Nicole Jackson, Anne U Wheeler, Eleanor Glazer, Nicole L Bouatia-Naji, Nabila Gloyn, Anna L Lindgren, Cecilia M Mägi, Reedik Morris, Andrew P Randall, Joshua Johnson, Toby Elliott, Paul Rybin, Denis Thorleifsson, Gudmar Steinthorsdottir, Valgerdur Henneman, Peter Grallert, Harald Dehghan, Abbas Hottenga, Jouke Jan Franklin, Christopher S Navarro, Pau Song, Kijoung Goel, Anuj Perry, John R B Egan, Josephine M Lajunen, Taina Grarup, Niels Sparsø, Thomas Doney, Alex Voight, Benjamin F Stringham, Heather M Li, Man Kanoni, Stavroula Shrader, Peter Cavalcanti-Proença, Christine Kumari, Meena Qi, Lu Timpson, Nicholas J Gieger, Christian Zabena, Carina Rocheleau, Ghislain Ingelsson, Erik An, Ping O’Connell, Jeffrey Luan, Jian'an Elliott, Amanda McCarroll, Steven A Payne, Felicity Roccasecca, Rosa Maria Pattou, François Sethupathy, Praveen Ardlie, Kristin Ariyurek, Yavuz Balkau, Beverley Barter, Philip Beilby, John P Ben-Shlomo, Yoav Benediktsson, Rafn Bennett, Amanda J Bergmann, Sven Bochud, Murielle Boerwinkle, Eric Bonnefond, Amélie Bonnycastle, Lori L Borch-Johnsen, Knut Böttcher, Yvonne Brunner, Eric Bumpstead, Suzannah J Charpentier, Guillaume Chen, Yii-Der Ida Chines, Peter Clarke, Robert Coin, Lachlan J M Cooper, Matthew N Cornelis, Marilyn Crawford, Gabe Crisponi, Laura Day, Ian N M de Geus, Eco Delplanque, Jerome Dina, Christian Erdos, Michael R Fedson, Annette C Fischer-Rosinsky, Antje Forouhi, Nita G Fox, Caroline S Frants, Rune Franzosi, Maria Grazia Galan, Pilar Goodarzi, Mark O Graessler, Jürgen Groves, Christopher J Grundy, Scott Gwilliam, Rhian Gyllensten, Ulf Hadjadj, Samy Hallmans, Göran Hammond, Naomi Han, Xijing Hartikainen, Anna-Liisa Hassanali, Neelam Hayward, Caroline Heath, Simon C Hercberg, Serge Herder, Christian Hicks, Andrew A Hillman, David R Hingorani, Aroon D Hofman, Albert Hui, Jennie Hung, Joe Isomaa, Bo Johnson, Paul R V Jørgensen, Torben Jula, Antti Kaakinen, Marika Kaprio, Jaakko Kesaniemi, Y Antero Kivimaki, Mika Knight, Beatrice Koskinen, Seppo Kovacs, Peter Kyvik, Kirsten Ohm Lathrop, G Mark Lawlor, Debbie A Le Bacquer, Olivier Lecoeur, Cécile Li, Yun Lyssenko, Valeriya Mahley, Robert Mangino, Massimo Manning, Alisa K Martínez-Larrad, María Teresa McAteer, Jarred B McCulloch, Laura J McPherson, Ruth Meisinger, Christa Melzer, David Meyre, David Mitchell, Braxton D Morken, Mario A Mukherjee, Sutapa Naitza, Silvia Narisu, Narisu Neville, Matthew J Oostra, Ben A Orrù, Marco Pakyz, Ruth Palmer, Colin N A Paolisso, Giuseppe Pattaro, Cristian Pearson, Daniel Peden, John F Pedersen, Nancy L. Perola, Markus Pfeiffer, Andreas F H Pichler, Irene Polasek, Ozren Posthuma, Danielle Potter, Simon C Pouta, Anneli Province, Michael A Psaty, Bruce M Rathmann, Wolfgang Rayner, Nigel W Rice, Kenneth Ripatti, Samuli Rivadeneira, Fernando Roden, Michael Rolandsson, Olov Sandbaek, Annelli Sandhu, Manjinder Sanna, Serena Sayer, Avan Aihie Scheet, Paul Scott, Laura J Seedorf, Udo Sharp, Stephen J Shields, Beverley Sigurðsson, Gunnar Sijbrands, Erik J G Silveira, Angela Simpson, Laila Singleton, Andrew Smith, Nicholas L Sovio, Ulla Swift, Amy Syddall, Holly Syvänen, Ann-Christine Tanaka, Toshiko Thorand, Barbara Tichet, Jean Tönjes, Anke Tuomi, Tiinamaija Uitterlinden, André G van Dijk, Ko Willems van Hoek, Mandy Varma, Dhiraj Visvikis-Siest, Sophie Vitart, Veronique Vogelzangs, Nicole Waeber, Gérard Wagner, Peter J Walley, Andrew Walters, G Bragi Ward, Kim L Watkins, Hugh Weedon, Michael N Wild, Sarah H Willemsen, Gonneke Witteman, Jaqueline C M Yarnell, John W G Zeggini, Eleftheria Zelenika, Diana Zethelius, Björn Zhai, Guangju Zhao, Jing Hua Zillikens, M Carola Borecki, Ingrid B Loos, Ruth J F Meneton, Pierre Magnusson, Patrik K E Nathan, David M Williams, Gordon H Hattersley, Andrew T Silander, Kaisa Salomaa, Veikko Smith, George Davey Bornstein, Stefan R Schwarz, Peter Spranger, Joachim Karpe, Fredrik Shuldiner, Alan R Cooper, Cyrus Dedoussis, George V Serrano-Ríos, Manuel Morris, Andrew D Lind, Lars Palmer, Lyle J Hu, Frank B. Franks, Paul W Ebrahim, Shah Marmot, Michael Kao, W H Linda Pankow, James S Sampson, Michael J Kuusisto, Johanna Laakso, Markku Hansen, Torben Pedersen, Oluf Pramstaller, Peter Paul Wichmann, H Erich Illig, Thomas Rudan, Igor Wright, Alan F Stumvoll, Michael Campbell, Harry Wilson, James F Hamsten, Anders Bergman, Richard N Buchanan, Thomas A Collins, Francis S Mohlke, Karen L Tuomilehto, Jaakko Valle, Timo T Altshuler, David Rotter, Jerome I Siscovick, David S Penninx, Brenda W J H Boomsma, Dorret Deloukas, Panos Spector, Timothy D Frayling, Timothy M Ferrucci, Luigi Kong, Augustine Thorsteinsdottir, Unnur Stefansson, Kari van Duijn, Cornelia M Aulchenko, Yurii S Cao, Antonio Scuteri, Angelo Schlessinger, David Uda, Manuela Ruokonen, Aimo Jarvelin, Marjo-Riitta Waterworth, Dawn M Vollenweider, Peter Peltonen, Leena Mooser, Vincent Abecasis, Goncalo R Wareham, Nicholas J Sladek, Robert Froguel, Philippe Watanabe, Richard M Meigs, James B Groop, Leif Boehnke, Michael McCarthy, Mark I Florez, Jose C Barroso, Inês |
| author_sort | Dupuis, Josée |
| collection | PubMed |
| description | Circulating glucose levels are tightly regulated. To identify novel glycemic loci, we performed meta-analyses of 21 genome-wide associations studies informative for fasting glucose (FG), fasting insulin (FI) and indices of β-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 non-diabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with FG/HOMA-B and two associated with FI/HOMA-IR. These include nine new FG loci (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and FAM148B) and one influencing FI/HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB/TMEM195 with type 2 diabetes (T2D). Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify T2D risk loci, as well as loci that elevate FG modestly, but do not cause overt diabetes. |
| format | Text |
| id | pubmed-3018764 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-30187642011-01-11 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Dupuis, Josée Langenberg, Claudia Prokopenko, Inga Saxena, Richa Soranzo, Nicole Jackson, Anne U Wheeler, Eleanor Glazer, Nicole L Bouatia-Naji, Nabila Gloyn, Anna L Lindgren, Cecilia M Mägi, Reedik Morris, Andrew P Randall, Joshua Johnson, Toby Elliott, Paul Rybin, Denis Thorleifsson, Gudmar Steinthorsdottir, Valgerdur Henneman, Peter Grallert, Harald Dehghan, Abbas Hottenga, Jouke Jan Franklin, Christopher S Navarro, Pau Song, Kijoung Goel, Anuj Perry, John R B Egan, Josephine M Lajunen, Taina Grarup, Niels Sparsø, Thomas Doney, Alex Voight, Benjamin F Stringham, Heather M Li, Man Kanoni, Stavroula Shrader, Peter Cavalcanti-Proença, Christine Kumari, Meena Qi, Lu Timpson, Nicholas J Gieger, Christian Zabena, Carina Rocheleau, Ghislain Ingelsson, Erik An, Ping O’Connell, Jeffrey Luan, Jian'an Elliott, Amanda McCarroll, Steven A Payne, Felicity Roccasecca, Rosa Maria Pattou, François Sethupathy, Praveen Ardlie, Kristin Ariyurek, Yavuz Balkau, Beverley Barter, Philip Beilby, John P Ben-Shlomo, Yoav Benediktsson, Rafn Bennett, Amanda J Bergmann, Sven Bochud, Murielle Boerwinkle, Eric Bonnefond, Amélie Bonnycastle, Lori L Borch-Johnsen, Knut Böttcher, Yvonne Brunner, Eric Bumpstead, Suzannah J Charpentier, Guillaume Chen, Yii-Der Ida Chines, Peter Clarke, Robert Coin, Lachlan J M Cooper, Matthew N Cornelis, Marilyn Crawford, Gabe Crisponi, Laura Day, Ian N M de Geus, Eco Delplanque, Jerome Dina, Christian Erdos, Michael R Fedson, Annette C Fischer-Rosinsky, Antje Forouhi, Nita G Fox, Caroline S Frants, Rune Franzosi, Maria Grazia Galan, Pilar Goodarzi, Mark O Graessler, Jürgen Groves, Christopher J Grundy, Scott Gwilliam, Rhian Gyllensten, Ulf Hadjadj, Samy Hallmans, Göran Hammond, Naomi Han, Xijing Hartikainen, Anna-Liisa Hassanali, Neelam Hayward, Caroline Heath, Simon C Hercberg, Serge Herder, Christian Hicks, Andrew A Hillman, David R Hingorani, Aroon D Hofman, Albert Hui, Jennie Hung, Joe Isomaa, Bo Johnson, Paul R V Jørgensen, Torben Jula, Antti Kaakinen, Marika Kaprio, Jaakko Kesaniemi, Y Antero Kivimaki, Mika Knight, Beatrice Koskinen, Seppo Kovacs, Peter Kyvik, Kirsten Ohm Lathrop, G Mark Lawlor, Debbie A Le Bacquer, Olivier Lecoeur, Cécile Li, Yun Lyssenko, Valeriya Mahley, Robert Mangino, Massimo Manning, Alisa K Martínez-Larrad, María Teresa McAteer, Jarred B McCulloch, Laura J McPherson, Ruth Meisinger, Christa Melzer, David Meyre, David Mitchell, Braxton D Morken, Mario A Mukherjee, Sutapa Naitza, Silvia Narisu, Narisu Neville, Matthew J Oostra, Ben A Orrù, Marco Pakyz, Ruth Palmer, Colin N A Paolisso, Giuseppe Pattaro, Cristian Pearson, Daniel Peden, John F Pedersen, Nancy L. Perola, Markus Pfeiffer, Andreas F H Pichler, Irene Polasek, Ozren Posthuma, Danielle Potter, Simon C Pouta, Anneli Province, Michael A Psaty, Bruce M Rathmann, Wolfgang Rayner, Nigel W Rice, Kenneth Ripatti, Samuli Rivadeneira, Fernando Roden, Michael Rolandsson, Olov Sandbaek, Annelli Sandhu, Manjinder Sanna, Serena Sayer, Avan Aihie Scheet, Paul Scott, Laura J Seedorf, Udo Sharp, Stephen J Shields, Beverley Sigurðsson, Gunnar Sijbrands, Erik J G Silveira, Angela Simpson, Laila Singleton, Andrew Smith, Nicholas L Sovio, Ulla Swift, Amy Syddall, Holly Syvänen, Ann-Christine Tanaka, Toshiko Thorand, Barbara Tichet, Jean Tönjes, Anke Tuomi, Tiinamaija Uitterlinden, André G van Dijk, Ko Willems van Hoek, Mandy Varma, Dhiraj Visvikis-Siest, Sophie Vitart, Veronique Vogelzangs, Nicole Waeber, Gérard Wagner, Peter J Walley, Andrew Walters, G Bragi Ward, Kim L Watkins, Hugh Weedon, Michael N Wild, Sarah H Willemsen, Gonneke Witteman, Jaqueline C M Yarnell, John W G Zeggini, Eleftheria Zelenika, Diana Zethelius, Björn Zhai, Guangju Zhao, Jing Hua Zillikens, M Carola Borecki, Ingrid B Loos, Ruth J F Meneton, Pierre Magnusson, Patrik K E Nathan, David M Williams, Gordon H Hattersley, Andrew T Silander, Kaisa Salomaa, Veikko Smith, George Davey Bornstein, Stefan R Schwarz, Peter Spranger, Joachim Karpe, Fredrik Shuldiner, Alan R Cooper, Cyrus Dedoussis, George V Serrano-Ríos, Manuel Morris, Andrew D Lind, Lars Palmer, Lyle J Hu, Frank B. Franks, Paul W Ebrahim, Shah Marmot, Michael Kao, W H Linda Pankow, James S Sampson, Michael J Kuusisto, Johanna Laakso, Markku Hansen, Torben Pedersen, Oluf Pramstaller, Peter Paul Wichmann, H Erich Illig, Thomas Rudan, Igor Wright, Alan F Stumvoll, Michael Campbell, Harry Wilson, James F Hamsten, Anders Bergman, Richard N Buchanan, Thomas A Collins, Francis S Mohlke, Karen L Tuomilehto, Jaakko Valle, Timo T Altshuler, David Rotter, Jerome I Siscovick, David S Penninx, Brenda W J H Boomsma, Dorret Deloukas, Panos Spector, Timothy D Frayling, Timothy M Ferrucci, Luigi Kong, Augustine Thorsteinsdottir, Unnur Stefansson, Kari van Duijn, Cornelia M Aulchenko, Yurii S Cao, Antonio Scuteri, Angelo Schlessinger, David Uda, Manuela Ruokonen, Aimo Jarvelin, Marjo-Riitta Waterworth, Dawn M Vollenweider, Peter Peltonen, Leena Mooser, Vincent Abecasis, Goncalo R Wareham, Nicholas J Sladek, Robert Froguel, Philippe Watanabe, Richard M Meigs, James B Groop, Leif Boehnke, Michael McCarthy, Mark I Florez, Jose C Barroso, Inês Nat Genet Article Circulating glucose levels are tightly regulated. To identify novel glycemic loci, we performed meta-analyses of 21 genome-wide associations studies informative for fasting glucose (FG), fasting insulin (FI) and indices of β-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 non-diabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with FG/HOMA-B and two associated with FI/HOMA-IR. These include nine new FG loci (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and FAM148B) and one influencing FI/HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB/TMEM195 with type 2 diabetes (T2D). Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify T2D risk loci, as well as loci that elevate FG modestly, but do not cause overt diabetes. 2010-01-17 2010-02 /pmc/articles/PMC3018764/ /pubmed/20081858 http://dx.doi.org/10.1038/ng.520 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Dupuis, Josée Langenberg, Claudia Prokopenko, Inga Saxena, Richa Soranzo, Nicole Jackson, Anne U Wheeler, Eleanor Glazer, Nicole L Bouatia-Naji, Nabila Gloyn, Anna L Lindgren, Cecilia M Mägi, Reedik Morris, Andrew P Randall, Joshua Johnson, Toby Elliott, Paul Rybin, Denis Thorleifsson, Gudmar Steinthorsdottir, Valgerdur Henneman, Peter Grallert, Harald Dehghan, Abbas Hottenga, Jouke Jan Franklin, Christopher S Navarro, Pau Song, Kijoung Goel, Anuj Perry, John R B Egan, Josephine M Lajunen, Taina Grarup, Niels Sparsø, Thomas Doney, Alex Voight, Benjamin F Stringham, Heather M Li, Man Kanoni, Stavroula Shrader, Peter Cavalcanti-Proença, Christine Kumari, Meena Qi, Lu Timpson, Nicholas J Gieger, Christian Zabena, Carina Rocheleau, Ghislain Ingelsson, Erik An, Ping O’Connell, Jeffrey Luan, Jian'an Elliott, Amanda McCarroll, Steven A Payne, Felicity Roccasecca, Rosa Maria Pattou, François Sethupathy, Praveen Ardlie, Kristin Ariyurek, Yavuz Balkau, Beverley Barter, Philip Beilby, John P Ben-Shlomo, Yoav Benediktsson, Rafn Bennett, Amanda J Bergmann, Sven Bochud, Murielle Boerwinkle, Eric Bonnefond, Amélie Bonnycastle, Lori L Borch-Johnsen, Knut Böttcher, Yvonne Brunner, Eric Bumpstead, Suzannah J Charpentier, Guillaume Chen, Yii-Der Ida Chines, Peter Clarke, Robert Coin, Lachlan J M Cooper, Matthew N Cornelis, Marilyn Crawford, Gabe Crisponi, Laura Day, Ian N M de Geus, Eco Delplanque, Jerome Dina, Christian Erdos, Michael R Fedson, Annette C Fischer-Rosinsky, Antje Forouhi, Nita G Fox, Caroline S Frants, Rune Franzosi, Maria Grazia Galan, Pilar Goodarzi, Mark O Graessler, Jürgen Groves, Christopher J Grundy, Scott Gwilliam, Rhian Gyllensten, Ulf Hadjadj, Samy Hallmans, Göran Hammond, Naomi Han, Xijing Hartikainen, Anna-Liisa Hassanali, Neelam Hayward, Caroline Heath, Simon C Hercberg, Serge Herder, Christian Hicks, Andrew A Hillman, David R Hingorani, Aroon D Hofman, Albert Hui, Jennie Hung, Joe Isomaa, Bo Johnson, Paul R V Jørgensen, Torben Jula, Antti Kaakinen, Marika Kaprio, Jaakko Kesaniemi, Y Antero Kivimaki, Mika Knight, Beatrice Koskinen, Seppo Kovacs, Peter Kyvik, Kirsten Ohm Lathrop, G Mark Lawlor, Debbie A Le Bacquer, Olivier Lecoeur, Cécile Li, Yun Lyssenko, Valeriya Mahley, Robert Mangino, Massimo Manning, Alisa K Martínez-Larrad, María Teresa McAteer, Jarred B McCulloch, Laura J McPherson, Ruth Meisinger, Christa Melzer, David Meyre, David Mitchell, Braxton D Morken, Mario A Mukherjee, Sutapa Naitza, Silvia Narisu, Narisu Neville, Matthew J Oostra, Ben A Orrù, Marco Pakyz, Ruth Palmer, Colin N A Paolisso, Giuseppe Pattaro, Cristian Pearson, Daniel Peden, John F Pedersen, Nancy L. Perola, Markus Pfeiffer, Andreas F H Pichler, Irene Polasek, Ozren Posthuma, Danielle Potter, Simon C Pouta, Anneli Province, Michael A Psaty, Bruce M Rathmann, Wolfgang Rayner, Nigel W Rice, Kenneth Ripatti, Samuli Rivadeneira, Fernando Roden, Michael Rolandsson, Olov Sandbaek, Annelli Sandhu, Manjinder Sanna, Serena Sayer, Avan Aihie Scheet, Paul Scott, Laura J Seedorf, Udo Sharp, Stephen J Shields, Beverley Sigurðsson, Gunnar Sijbrands, Erik J G Silveira, Angela Simpson, Laila Singleton, Andrew Smith, Nicholas L Sovio, Ulla Swift, Amy Syddall, Holly Syvänen, Ann-Christine Tanaka, Toshiko Thorand, Barbara Tichet, Jean Tönjes, Anke Tuomi, Tiinamaija Uitterlinden, André G van Dijk, Ko Willems van Hoek, Mandy Varma, Dhiraj Visvikis-Siest, Sophie Vitart, Veronique Vogelzangs, Nicole Waeber, Gérard Wagner, Peter J Walley, Andrew Walters, G Bragi Ward, Kim L Watkins, Hugh Weedon, Michael N Wild, Sarah H Willemsen, Gonneke Witteman, Jaqueline C M Yarnell, John W G Zeggini, Eleftheria Zelenika, Diana Zethelius, Björn Zhai, Guangju Zhao, Jing Hua Zillikens, M Carola Borecki, Ingrid B Loos, Ruth J F Meneton, Pierre Magnusson, Patrik K E Nathan, David M Williams, Gordon H Hattersley, Andrew T Silander, Kaisa Salomaa, Veikko Smith, George Davey Bornstein, Stefan R Schwarz, Peter Spranger, Joachim Karpe, Fredrik Shuldiner, Alan R Cooper, Cyrus Dedoussis, George V Serrano-Ríos, Manuel Morris, Andrew D Lind, Lars Palmer, Lyle J Hu, Frank B. Franks, Paul W Ebrahim, Shah Marmot, Michael Kao, W H Linda Pankow, James S Sampson, Michael J Kuusisto, Johanna Laakso, Markku Hansen, Torben Pedersen, Oluf Pramstaller, Peter Paul Wichmann, H Erich Illig, Thomas Rudan, Igor Wright, Alan F Stumvoll, Michael Campbell, Harry Wilson, James F Hamsten, Anders Bergman, Richard N Buchanan, Thomas A Collins, Francis S Mohlke, Karen L Tuomilehto, Jaakko Valle, Timo T Altshuler, David Rotter, Jerome I Siscovick, David S Penninx, Brenda W J H Boomsma, Dorret Deloukas, Panos Spector, Timothy D Frayling, Timothy M Ferrucci, Luigi Kong, Augustine Thorsteinsdottir, Unnur Stefansson, Kari van Duijn, Cornelia M Aulchenko, Yurii S Cao, Antonio Scuteri, Angelo Schlessinger, David Uda, Manuela Ruokonen, Aimo Jarvelin, Marjo-Riitta Waterworth, Dawn M Vollenweider, Peter Peltonen, Leena Mooser, Vincent Abecasis, Goncalo R Wareham, Nicholas J Sladek, Robert Froguel, Philippe Watanabe, Richard M Meigs, James B Groop, Leif Boehnke, Michael McCarthy, Mark I Florez, Jose C Barroso, Inês New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk |
| title | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk |
| title_full | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk |
| title_fullStr | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk |
| title_full_unstemmed | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk |
| title_short | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk |
| title_sort | new genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018764/ https://www.ncbi.nlm.nih.gov/pubmed/20081858 http://dx.doi.org/10.1038/ng.520 |
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