A DNA Vaccine against Chikungunya Virus Is Protective in Mice and Induces Neutralizing Antibodies in Mice and Nonhuman Primates

Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus indigenous to tropical Africa and Asia. Acute illness is characterized by fever, arthralgias, conjunctivitis, rash, and sometimes arthritis. Relatively little is known about the antigenic targets for immunity, and no licensed vaccine...

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Detalles Bibliográficos
Autores principales: Mallilankaraman, Karthik, Shedlock, Devon J., Bao, Huihui, Kawalekar, Omkar U., Fagone, Paolo, Ramanathan, Aarthi A., Ferraro, Bernadette, Stabenow, Jennifer, Vijayachari, Paluru, Sundaram, Senthil G., Muruganandam, Nagarajan, Sarangan, Gopalsamy, Srikanth, Padma, Khan, Amir S., Lewis, Mark G., Kim, J. Joseph, Sardesai, Niranjan Y., Muthumani, Karuppiah, Weiner, David B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019110/
https://www.ncbi.nlm.nih.gov/pubmed/21264351
http://dx.doi.org/10.1371/journal.pntd.0000928

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