Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

BACKGROUND: SHANK3 is a protein in the core of the postsynaptic density (PSD) and has a critical role in recruiting many key functional elements to the PSD and to the synapse, including components of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid (AMPA), metabotropic glutamate (mGlu) and N-m...

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Detalles Bibliográficos
Autores principales: Bozdagi, Ozlem, Sakurai, Takeshi, Papapetrou, Danae, Wang, Xiaobin, Dickstein, Dara L, Takahashi, Nagahide, Kajiwara, Yuji, Yang, Mu, Katz, Adam M, Scattoni, Maria Luisa, Harris, Mark J, Saxena, Roheeni, Silverman, Jill L, Crawley, Jacqueline N, Zhou, Qiang, Hof, Patrick R, Buxbaum, Joseph D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019144/
https://www.ncbi.nlm.nih.gov/pubmed/21167025
http://dx.doi.org/10.1186/2040-2392-1-15

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