LINGO1 Variants in the French-Canadian Population

Essential tremor (ET) is a complex genetic disorder for which no causative gene has been found. Recently, a genome-wide association study reported that two variants in the LINGO1 locus were associated to this disease. The aim of the present study was to test if this specific association could be rep...

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Autores principales: Bourassa, Cynthia V., Rivière, Jean-Baptiste, Dion, Patrick A., Bernard, Geneviève, Diab, Sabrina, Panisset, Michel, Chouinard, Sylvain, Dupré, Nicolas, Fournier, Hélène, Raelson, John, Belouchi, Majid, Rouleau, Guy A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019170/
https://www.ncbi.nlm.nih.gov/pubmed/21264305
http://dx.doi.org/10.1371/journal.pone.0016254
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author Bourassa, Cynthia V.
Rivière, Jean-Baptiste
Dion, Patrick A.
Bernard, Geneviève
Diab, Sabrina
Panisset, Michel
Chouinard, Sylvain
Dupré, Nicolas
Fournier, Hélène
Raelson, John
Belouchi, Majid
Rouleau, Guy A.
author_facet Bourassa, Cynthia V.
Rivière, Jean-Baptiste
Dion, Patrick A.
Bernard, Geneviève
Diab, Sabrina
Panisset, Michel
Chouinard, Sylvain
Dupré, Nicolas
Fournier, Hélène
Raelson, John
Belouchi, Majid
Rouleau, Guy A.
author_sort Bourassa, Cynthia V.
collection PubMed
description Essential tremor (ET) is a complex genetic disorder for which no causative gene has been found. Recently, a genome-wide association study reported that two variants in the LINGO1 locus were associated to this disease. The aim of the present study was to test if this specific association could be replicated using a French-Canadian cohort of 259 ET patients and 479 ethnically matched controls. Our genotyping results lead us to conclude that no association exists between the key variant rs9652490 and ET (P(corr) = 1.00).
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spelling pubmed-30191702011-01-24 LINGO1 Variants in the French-Canadian Population Bourassa, Cynthia V. Rivière, Jean-Baptiste Dion, Patrick A. Bernard, Geneviève Diab, Sabrina Panisset, Michel Chouinard, Sylvain Dupré, Nicolas Fournier, Hélène Raelson, John Belouchi, Majid Rouleau, Guy A. PLoS One Research Article Essential tremor (ET) is a complex genetic disorder for which no causative gene has been found. Recently, a genome-wide association study reported that two variants in the LINGO1 locus were associated to this disease. The aim of the present study was to test if this specific association could be replicated using a French-Canadian cohort of 259 ET patients and 479 ethnically matched controls. Our genotyping results lead us to conclude that no association exists between the key variant rs9652490 and ET (P(corr) = 1.00). Public Library of Science 2011-01-11 /pmc/articles/PMC3019170/ /pubmed/21264305 http://dx.doi.org/10.1371/journal.pone.0016254 Text en Bourassa, et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Bourassa, Cynthia V.
Rivière, Jean-Baptiste
Dion, Patrick A.
Bernard, Geneviève
Diab, Sabrina
Panisset, Michel
Chouinard, Sylvain
Dupré, Nicolas
Fournier, Hélène
Raelson, John
Belouchi, Majid
Rouleau, Guy A.
LINGO1 Variants in the French-Canadian Population
title LINGO1 Variants in the French-Canadian Population
title_full LINGO1 Variants in the French-Canadian Population
title_fullStr LINGO1 Variants in the French-Canadian Population
title_full_unstemmed LINGO1 Variants in the French-Canadian Population
title_short LINGO1 Variants in the French-Canadian Population
title_sort lingo1 variants in the french-canadian population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019170/
https://www.ncbi.nlm.nih.gov/pubmed/21264305
http://dx.doi.org/10.1371/journal.pone.0016254
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