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Making heads or tails of phospholipids in mitochondria
Mitochondria are dynamic organelles whose functional integrity requires a coordinated supply of proteins and phospholipids. Defined functions of specific phospholipids, like the mitochondrial signature lipid cardiolipin, are emerging in diverse processes, ranging from protein biogenesis and energy p...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019561/ https://www.ncbi.nlm.nih.gov/pubmed/21220505 http://dx.doi.org/10.1083/jcb.201006159 |
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author | Osman, Christof Voelker, Dennis R. Langer, Thomas |
author_facet | Osman, Christof Voelker, Dennis R. Langer, Thomas |
author_sort | Osman, Christof |
collection | PubMed |
description | Mitochondria are dynamic organelles whose functional integrity requires a coordinated supply of proteins and phospholipids. Defined functions of specific phospholipids, like the mitochondrial signature lipid cardiolipin, are emerging in diverse processes, ranging from protein biogenesis and energy production to membrane fusion and apoptosis. The accumulation of phospholipids within mitochondria depends on interorganellar lipid transport between the endoplasmic reticulum (ER) and mitochondria as well as intramitochondrial lipid trafficking. The discovery of proteins that regulate mitochondrial membrane lipid composition and of a multiprotein complex tethering ER to mitochondrial membranes has unveiled novel mechanisms of mitochondrial membrane biogenesis. |
format | Text |
id | pubmed-3019561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-30195612011-07-10 Making heads or tails of phospholipids in mitochondria Osman, Christof Voelker, Dennis R. Langer, Thomas J Cell Biol Reviews Mitochondria are dynamic organelles whose functional integrity requires a coordinated supply of proteins and phospholipids. Defined functions of specific phospholipids, like the mitochondrial signature lipid cardiolipin, are emerging in diverse processes, ranging from protein biogenesis and energy production to membrane fusion and apoptosis. The accumulation of phospholipids within mitochondria depends on interorganellar lipid transport between the endoplasmic reticulum (ER) and mitochondria as well as intramitochondrial lipid trafficking. The discovery of proteins that regulate mitochondrial membrane lipid composition and of a multiprotein complex tethering ER to mitochondrial membranes has unveiled novel mechanisms of mitochondrial membrane biogenesis. The Rockefeller University Press 2011-01-10 /pmc/articles/PMC3019561/ /pubmed/21220505 http://dx.doi.org/10.1083/jcb.201006159 Text en © 2011 Osman et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Reviews Osman, Christof Voelker, Dennis R. Langer, Thomas Making heads or tails of phospholipids in mitochondria |
title | Making heads or tails of phospholipids in mitochondria |
title_full | Making heads or tails of phospholipids in mitochondria |
title_fullStr | Making heads or tails of phospholipids in mitochondria |
title_full_unstemmed | Making heads or tails of phospholipids in mitochondria |
title_short | Making heads or tails of phospholipids in mitochondria |
title_sort | making heads or tails of phospholipids in mitochondria |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019561/ https://www.ncbi.nlm.nih.gov/pubmed/21220505 http://dx.doi.org/10.1083/jcb.201006159 |
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