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Making heads or tails of phospholipids in mitochondria

Mitochondria are dynamic organelles whose functional integrity requires a coordinated supply of proteins and phospholipids. Defined functions of specific phospholipids, like the mitochondrial signature lipid cardiolipin, are emerging in diverse processes, ranging from protein biogenesis and energy p...

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Detalles Bibliográficos
Autores principales: Osman, Christof, Voelker, Dennis R., Langer, Thomas
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019561/
https://www.ncbi.nlm.nih.gov/pubmed/21220505
http://dx.doi.org/10.1083/jcb.201006159
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author Osman, Christof
Voelker, Dennis R.
Langer, Thomas
author_facet Osman, Christof
Voelker, Dennis R.
Langer, Thomas
author_sort Osman, Christof
collection PubMed
description Mitochondria are dynamic organelles whose functional integrity requires a coordinated supply of proteins and phospholipids. Defined functions of specific phospholipids, like the mitochondrial signature lipid cardiolipin, are emerging in diverse processes, ranging from protein biogenesis and energy production to membrane fusion and apoptosis. The accumulation of phospholipids within mitochondria depends on interorganellar lipid transport between the endoplasmic reticulum (ER) and mitochondria as well as intramitochondrial lipid trafficking. The discovery of proteins that regulate mitochondrial membrane lipid composition and of a multiprotein complex tethering ER to mitochondrial membranes has unveiled novel mechanisms of mitochondrial membrane biogenesis.
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spelling pubmed-30195612011-07-10 Making heads or tails of phospholipids in mitochondria Osman, Christof Voelker, Dennis R. Langer, Thomas J Cell Biol Reviews Mitochondria are dynamic organelles whose functional integrity requires a coordinated supply of proteins and phospholipids. Defined functions of specific phospholipids, like the mitochondrial signature lipid cardiolipin, are emerging in diverse processes, ranging from protein biogenesis and energy production to membrane fusion and apoptosis. The accumulation of phospholipids within mitochondria depends on interorganellar lipid transport between the endoplasmic reticulum (ER) and mitochondria as well as intramitochondrial lipid trafficking. The discovery of proteins that regulate mitochondrial membrane lipid composition and of a multiprotein complex tethering ER to mitochondrial membranes has unveiled novel mechanisms of mitochondrial membrane biogenesis. The Rockefeller University Press 2011-01-10 /pmc/articles/PMC3019561/ /pubmed/21220505 http://dx.doi.org/10.1083/jcb.201006159 Text en © 2011 Osman et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Osman, Christof
Voelker, Dennis R.
Langer, Thomas
Making heads or tails of phospholipids in mitochondria
title Making heads or tails of phospholipids in mitochondria
title_full Making heads or tails of phospholipids in mitochondria
title_fullStr Making heads or tails of phospholipids in mitochondria
title_full_unstemmed Making heads or tails of phospholipids in mitochondria
title_short Making heads or tails of phospholipids in mitochondria
title_sort making heads or tails of phospholipids in mitochondria
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019561/
https://www.ncbi.nlm.nih.gov/pubmed/21220505
http://dx.doi.org/10.1083/jcb.201006159
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