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Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome

PURPOSE: To assess the clinical utility of a recently developed highly sensitive cardiac troponin T (hs-cTnT) assay for providing prognostic information on patients with sepsis. METHODS: cTnT levels were measured by the novel hs-cTnT assay at two time points (inclusion and 72 h thereafter) in a subg...

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Autores principales: Røsjø, Helge, Varpula, Marjut, Hagve, Tor-Arne, Karlsson, Sari, Ruokonen, Esko, Pettilä, Ville, Omland, Torbjørn
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020309/
https://www.ncbi.nlm.nih.gov/pubmed/20938765
http://dx.doi.org/10.1007/s00134-010-2051-x
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author Røsjø, Helge
Varpula, Marjut
Hagve, Tor-Arne
Karlsson, Sari
Ruokonen, Esko
Pettilä, Ville
Omland, Torbjørn
author_facet Røsjø, Helge
Varpula, Marjut
Hagve, Tor-Arne
Karlsson, Sari
Ruokonen, Esko
Pettilä, Ville
Omland, Torbjørn
author_sort Røsjø, Helge
collection PubMed
description PURPOSE: To assess the clinical utility of a recently developed highly sensitive cardiac troponin T (hs-cTnT) assay for providing prognostic information on patients with sepsis. METHODS: cTnT levels were measured by the novel hs-cTnT assay at two time points (inclusion and 72 h thereafter) in a subgroup of patients from the FINNSEPSIS study and associations with clinical outcomes were examined. Results for the hs-cTnT assay were compared to those of the established fourth-generation cTnT assay. RESULTS: cTnT measured by the fourth-generation and hs-cTnT assay was detectable in 124 (60%) and 207 (100%) patients, respectively, on inclusion in this study. hs-cTnT levels on inclusion correlated with several indices of risk in sepsis, including the simplified acute physiology score (SAPS) II and sequential organ failure assessment (SOFA) scores. The level of hs-cTnT on inclusion was higher in hospital non-survivors (n = 47) than survivors (n = 160) (median 0.054 [Q1–3, 0.022–0.227] versus 0.035 [0.015–0.111] μg/L, P = 0.047), but hs-cTnT level was not an independent predictor of in-hospital mortality. hs-cTnT levels on inclusion were also higher in patients with septic shock during the hospitalization (0.044 [0.024–0.171] versus 0.033 [0.012–0.103] μg/L, P = 0.03), while this was not the case for the fourth-generation cTnT assay or NT-proBNP levels. CONCLUSIONS: Circulating hs-cTnT is present in patients with severe sepsis and septic shock, associates with disease severity and survival, but does not add to SAPS II score for prediction of mortality. hs-cTnT measurement could still have a role in sepsis as an early marker of shock. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00134-010-2051-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-30203092011-02-22 Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome Røsjø, Helge Varpula, Marjut Hagve, Tor-Arne Karlsson, Sari Ruokonen, Esko Pettilä, Ville Omland, Torbjørn Intensive Care Med Original PURPOSE: To assess the clinical utility of a recently developed highly sensitive cardiac troponin T (hs-cTnT) assay for providing prognostic information on patients with sepsis. METHODS: cTnT levels were measured by the novel hs-cTnT assay at two time points (inclusion and 72 h thereafter) in a subgroup of patients from the FINNSEPSIS study and associations with clinical outcomes were examined. Results for the hs-cTnT assay were compared to those of the established fourth-generation cTnT assay. RESULTS: cTnT measured by the fourth-generation and hs-cTnT assay was detectable in 124 (60%) and 207 (100%) patients, respectively, on inclusion in this study. hs-cTnT levels on inclusion correlated with several indices of risk in sepsis, including the simplified acute physiology score (SAPS) II and sequential organ failure assessment (SOFA) scores. The level of hs-cTnT on inclusion was higher in hospital non-survivors (n = 47) than survivors (n = 160) (median 0.054 [Q1–3, 0.022–0.227] versus 0.035 [0.015–0.111] μg/L, P = 0.047), but hs-cTnT level was not an independent predictor of in-hospital mortality. hs-cTnT levels on inclusion were also higher in patients with septic shock during the hospitalization (0.044 [0.024–0.171] versus 0.033 [0.012–0.103] μg/L, P = 0.03), while this was not the case for the fourth-generation cTnT assay or NT-proBNP levels. CONCLUSIONS: Circulating hs-cTnT is present in patients with severe sepsis and septic shock, associates with disease severity and survival, but does not add to SAPS II score for prediction of mortality. hs-cTnT measurement could still have a role in sepsis as an early marker of shock. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00134-010-2051-x) contains supplementary material, which is available to authorized users. Springer-Verlag 2010-10-12 2011 /pmc/articles/PMC3020309/ /pubmed/20938765 http://dx.doi.org/10.1007/s00134-010-2051-x Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original
Røsjø, Helge
Varpula, Marjut
Hagve, Tor-Arne
Karlsson, Sari
Ruokonen, Esko
Pettilä, Ville
Omland, Torbjørn
Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome
title Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome
title_full Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome
title_fullStr Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome
title_full_unstemmed Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome
title_short Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome
title_sort circulating high sensitivity troponin t in severe sepsis and septic shock: distribution, associated factors, and relation to outcome
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020309/
https://www.ncbi.nlm.nih.gov/pubmed/20938765
http://dx.doi.org/10.1007/s00134-010-2051-x
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