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Clinical and epidemiological aspects of hepatocellular carcinoma in Brazil

OBJECTIVES: We performed a national survey to update hepatocellular carcinoma (HCC) epidemiology in Brazil and determined the clinical and epidemiological profiles of patients with HCC in different Brazilian regions. METHODS: Data from 29 centers included 1,405 patients diagnosed with HCC from 2004...

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Autores principales: Carrilho, Flair Jose, Kikuchi, Luciana, Branco, Fernanda, Gonçalves, Carlos Sandoval, de Mattos, Angelo Aves
Formato: Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020338/
https://www.ncbi.nlm.nih.gov/pubmed/21340216
http://dx.doi.org/10.1590/S1807-59322010001200010
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author Carrilho, Flair Jose
Kikuchi, Luciana
Branco, Fernanda
Gonçalves, Carlos Sandoval
de Mattos, Angelo Aves
author_facet Carrilho, Flair Jose
Kikuchi, Luciana
Branco, Fernanda
Gonçalves, Carlos Sandoval
de Mattos, Angelo Aves
author_sort Carrilho, Flair Jose
collection PubMed
description OBJECTIVES: We performed a national survey to update hepatocellular carcinoma (HCC) epidemiology in Brazil and determined the clinical and epidemiological profiles of patients with HCC in different Brazilian regions. METHODS: Data from 29 centers included 1,405 patients diagnosed with HCC from 2004 to 2009. RESULTS: The median age was 59 (1–92 years old; 78% male). At diagnosis, females were older than males (median age: 62 vs. 59 years old respectively; p<0.0001). Ninety‐eight percent of the patients had cirrhosis (1279/1308). Hepatitis C virus was the main etiology (54%), followed by hepatitis B virus (16%) and alcohol (14%). In Southeastern and Southern Brazil, hepatitis C virus accounted for over 55% of cases. In the Northeast and North, hepatitis C virus accounted for less than 50%, and hepatitis B virus accounted for 22–25% of cases; hepatitis B was more prevalent in the Northern than in the Southern regions. Some 43%, 35%, and 22% of patients were in early, intermediate, and advanced stages respectively. Initial therapies for HCC included chemoembolization or embolization (36%), percutaneous ablation (13%), liver resection (7%), and sorafenib (1%). Liver transplantation was performed in 242 patients (19%), but it was the initial therapy for only 56 patients (4%). CONCLUSION: The epidemiology, classification, and therapy selection for HCC varied among Brazilian regions. Hepatitis C infection was the most common etiology of liver cirrhosis; chemoembolization was the most common therapy employed. Liver cirrhosis was the main risk factor for HCC development in Brazil.
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spelling pubmed-30203382011-01-16 Clinical and epidemiological aspects of hepatocellular carcinoma in Brazil Carrilho, Flair Jose Kikuchi, Luciana Branco, Fernanda Gonçalves, Carlos Sandoval de Mattos, Angelo Aves Clinics (Sao Paulo) Clinical Science OBJECTIVES: We performed a national survey to update hepatocellular carcinoma (HCC) epidemiology in Brazil and determined the clinical and epidemiological profiles of patients with HCC in different Brazilian regions. METHODS: Data from 29 centers included 1,405 patients diagnosed with HCC from 2004 to 2009. RESULTS: The median age was 59 (1–92 years old; 78% male). At diagnosis, females were older than males (median age: 62 vs. 59 years old respectively; p<0.0001). Ninety‐eight percent of the patients had cirrhosis (1279/1308). Hepatitis C virus was the main etiology (54%), followed by hepatitis B virus (16%) and alcohol (14%). In Southeastern and Southern Brazil, hepatitis C virus accounted for over 55% of cases. In the Northeast and North, hepatitis C virus accounted for less than 50%, and hepatitis B virus accounted for 22–25% of cases; hepatitis B was more prevalent in the Northern than in the Southern regions. Some 43%, 35%, and 22% of patients were in early, intermediate, and advanced stages respectively. Initial therapies for HCC included chemoembolization or embolization (36%), percutaneous ablation (13%), liver resection (7%), and sorafenib (1%). Liver transplantation was performed in 242 patients (19%), but it was the initial therapy for only 56 patients (4%). CONCLUSION: The epidemiology, classification, and therapy selection for HCC varied among Brazilian regions. Hepatitis C infection was the most common etiology of liver cirrhosis; chemoembolization was the most common therapy employed. Liver cirrhosis was the main risk factor for HCC development in Brazil. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2010-12 /pmc/articles/PMC3020338/ /pubmed/21340216 http://dx.doi.org/10.1590/S1807-59322010001200010 Text en Copyright © 2010 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Science
Carrilho, Flair Jose
Kikuchi, Luciana
Branco, Fernanda
Gonçalves, Carlos Sandoval
de Mattos, Angelo Aves
Clinical and epidemiological aspects of hepatocellular carcinoma in Brazil
title Clinical and epidemiological aspects of hepatocellular carcinoma in Brazil
title_full Clinical and epidemiological aspects of hepatocellular carcinoma in Brazil
title_fullStr Clinical and epidemiological aspects of hepatocellular carcinoma in Brazil
title_full_unstemmed Clinical and epidemiological aspects of hepatocellular carcinoma in Brazil
title_short Clinical and epidemiological aspects of hepatocellular carcinoma in Brazil
title_sort clinical and epidemiological aspects of hepatocellular carcinoma in brazil
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020338/
https://www.ncbi.nlm.nih.gov/pubmed/21340216
http://dx.doi.org/10.1590/S1807-59322010001200010
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