NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America

An imipenem-resistant Enterobacter cloacae isolate was recovered from the blood of a patient with a hematologic malignancy. Analytical isoelectric focusing, inhibitor studies, hydrolysis, induction assays, and molecular sequencing methods confirmed the presence of a NmcA carbapenem-hydrolyzing enzym...

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Detalles Bibliográficos
Autores principales: Pottumarthy, Sudha, Moland, Ellen Smith, Juretschko, Stefan, Swanzy, Susan R., Thomson, Kenneth S., Fritsche, Thomas R.
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2003
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020613/
https://www.ncbi.nlm.nih.gov/pubmed/12967501
http://dx.doi.org/10.3201/eid0908.030096
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author Pottumarthy, Sudha
Moland, Ellen Smith
Juretschko, Stefan
Swanzy, Susan R.
Thomson, Kenneth S.
Fritsche, Thomas R.
author_facet Pottumarthy, Sudha
Moland, Ellen Smith
Juretschko, Stefan
Swanzy, Susan R.
Thomson, Kenneth S.
Fritsche, Thomas R.
author_sort Pottumarthy, Sudha
collection PubMed
description An imipenem-resistant Enterobacter cloacae isolate was recovered from the blood of a patient with a hematologic malignancy. Analytical isoelectric focusing, inhibitor studies, hydrolysis, induction assays, and molecular sequencing methods confirmed the presence of a NmcA carbapenem-hydrolyzing enzyme. This first report of NmcA detected in North America warrants further investigation into its distribution and clinical impact.
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spelling pubmed-30206132011-01-27 NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America Pottumarthy, Sudha Moland, Ellen Smith Juretschko, Stefan Swanzy, Susan R. Thomson, Kenneth S. Fritsche, Thomas R. Emerg Infect Dis Dispatch An imipenem-resistant Enterobacter cloacae isolate was recovered from the blood of a patient with a hematologic malignancy. Analytical isoelectric focusing, inhibitor studies, hydrolysis, induction assays, and molecular sequencing methods confirmed the presence of a NmcA carbapenem-hydrolyzing enzyme. This first report of NmcA detected in North America warrants further investigation into its distribution and clinical impact. Centers for Disease Control and Prevention 2003-08 /pmc/articles/PMC3020613/ /pubmed/12967501 http://dx.doi.org/10.3201/eid0908.030096 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Pottumarthy, Sudha
Moland, Ellen Smith
Juretschko, Stefan
Swanzy, Susan R.
Thomson, Kenneth S.
Fritsche, Thomas R.
NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America
title NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America
title_full NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America
title_fullStr NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America
title_full_unstemmed NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America
title_short NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America
title_sort nmca carbapenem-hydrolyzing enzyme in enterobacter cloacae in north america
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020613/
https://www.ncbi.nlm.nih.gov/pubmed/12967501
http://dx.doi.org/10.3201/eid0908.030096
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AT swanzysusanr nmcacarbapenemhydrolyzingenzymeinenterobactercloacaeinnorthamerica
AT thomsonkenneths nmcacarbapenemhydrolyzingenzymeinenterobactercloacaeinnorthamerica
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