Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans

Histone deacetylase (HDAC) inhibitors induce cell cycle arrest, differentiation or apoptosis in tumour cells and are, therefore, promising anti-cancer reagents. However, the specific HDAC isoforms that mediate these effects are not yet identified. To explore the role of HDAC1 in tumourigenesis and t...

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Detalles Bibliográficos
Autores principales: Lagger, Sabine, Meunier, Dominique, Mikula, Mario, Brunmeir, Reinhard, Schlederer, Michaela, Artaker, Matthias, Pusch, Oliver, Egger, Gerda, Hagelkruys, Astrid, Mikulits, Wolfgang, Weitzer, Georg, Muellner, Ernst W, Susani, Martin, Kenner, Lukas, Seiser, Christian
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020644/
https://www.ncbi.nlm.nih.gov/pubmed/20967026
http://dx.doi.org/10.1038/emboj.2010.264

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