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Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy
Heritable changes in gene expression that are not based upon alterations in the DNA sequence are defined as epigenetics. The most common mechanisms of epigenetic regulation are the methylation of CpG islands within the DNA and the modification of amino acids in the N-terminal histone tails. In the l...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020651/ https://www.ncbi.nlm.nih.gov/pubmed/21258646 http://dx.doi.org/10.1007/s13148-010-0012-4 |