Cargando…

The ABO blood group and Plasmodium falciparum malaria in Awash, Metehara and Ziway areas, Ethiopia

BACKGROUND: The virulence of Plasmodium falciparum is associated with the capacity of the infected red blood cell (iRBC) to adhere to uninfected RBCs, a process known as rosetting, which has been linked to the occurrence of severe malaria. The present study was carried out in three Ethiopian malaria...

Descripción completa

Detalles Bibliográficos
Autores principales: Tekeste, Zinaye, Petros, Beyene
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020677/
https://www.ncbi.nlm.nih.gov/pubmed/20939876
http://dx.doi.org/10.1186/1475-2875-9-280
_version_ 1782196321021591552
author Tekeste, Zinaye
Petros, Beyene
author_facet Tekeste, Zinaye
Petros, Beyene
author_sort Tekeste, Zinaye
collection PubMed
description BACKGROUND: The virulence of Plasmodium falciparum is associated with the capacity of the infected red blood cell (iRBC) to adhere to uninfected RBCs, a process known as rosetting, which has been linked to the occurrence of severe malaria. The present study was carried out in three Ethiopian malaria endemic localities to investigate the relationship between blood group type and severe disease in falciparum malaria. METHODS: A total of 210 cases of malaria (70 severe and 140 uncomplicated) and 190 healthy controls participated in the study. Patients with at least one of the severe malaria syndromes (cerebral malaria, severe anaemia and circulatory collapse) were considered as severe malaria cases. RESULTS: In the severe malaria category, there were 25 (35.7%), 15 (21.4%), 14 (20%) and 16 (22.9%) blood group A, B, AB and O patients, respectively. Blood group O was the dominant blood type in both uncomplicated malaria (45.7%) and healthy controls (41.6%). A case of severe malaria was almost twice as likely to be of type A as to be of type O (odds ratio (OR) 0.42, 95% confidence interval (CI) 0.20-0.88, P = 0.019), and more than twice as likely to be of type B as to be of type O (OR 0.38, 95% CI 0.16-0.89, P = 0.02). Furthermore, individuals with severe malaria were about six fold less likely to be of O as to be of type AB (OR 0.19, 95% CI 0.07-0.51, P = 0.0005). CONCLUSION: The study revealed that on the basis of the three criteria (cerebral malaria, severe anaemia and circulatory collapse) used to determine severity in P. falciparum malaria, patients with blood group O, which is less prone to rosetting have a reduced chance of developing severe falciparum malaria as compared to patients with other blood groups.
format Text
id pubmed-3020677
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-30206772011-01-14 The ABO blood group and Plasmodium falciparum malaria in Awash, Metehara and Ziway areas, Ethiopia Tekeste, Zinaye Petros, Beyene Malar J Research BACKGROUND: The virulence of Plasmodium falciparum is associated with the capacity of the infected red blood cell (iRBC) to adhere to uninfected RBCs, a process known as rosetting, which has been linked to the occurrence of severe malaria. The present study was carried out in three Ethiopian malaria endemic localities to investigate the relationship between blood group type and severe disease in falciparum malaria. METHODS: A total of 210 cases of malaria (70 severe and 140 uncomplicated) and 190 healthy controls participated in the study. Patients with at least one of the severe malaria syndromes (cerebral malaria, severe anaemia and circulatory collapse) were considered as severe malaria cases. RESULTS: In the severe malaria category, there were 25 (35.7%), 15 (21.4%), 14 (20%) and 16 (22.9%) blood group A, B, AB and O patients, respectively. Blood group O was the dominant blood type in both uncomplicated malaria (45.7%) and healthy controls (41.6%). A case of severe malaria was almost twice as likely to be of type A as to be of type O (odds ratio (OR) 0.42, 95% confidence interval (CI) 0.20-0.88, P = 0.019), and more than twice as likely to be of type B as to be of type O (OR 0.38, 95% CI 0.16-0.89, P = 0.02). Furthermore, individuals with severe malaria were about six fold less likely to be of O as to be of type AB (OR 0.19, 95% CI 0.07-0.51, P = 0.0005). CONCLUSION: The study revealed that on the basis of the three criteria (cerebral malaria, severe anaemia and circulatory collapse) used to determine severity in P. falciparum malaria, patients with blood group O, which is less prone to rosetting have a reduced chance of developing severe falciparum malaria as compared to patients with other blood groups. BioMed Central 2010-10-12 /pmc/articles/PMC3020677/ /pubmed/20939876 http://dx.doi.org/10.1186/1475-2875-9-280 Text en Copyright ©2010 Tekeste and Petros; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Tekeste, Zinaye
Petros, Beyene
The ABO blood group and Plasmodium falciparum malaria in Awash, Metehara and Ziway areas, Ethiopia
title The ABO blood group and Plasmodium falciparum malaria in Awash, Metehara and Ziway areas, Ethiopia
title_full The ABO blood group and Plasmodium falciparum malaria in Awash, Metehara and Ziway areas, Ethiopia
title_fullStr The ABO blood group and Plasmodium falciparum malaria in Awash, Metehara and Ziway areas, Ethiopia
title_full_unstemmed The ABO blood group and Plasmodium falciparum malaria in Awash, Metehara and Ziway areas, Ethiopia
title_short The ABO blood group and Plasmodium falciparum malaria in Awash, Metehara and Ziway areas, Ethiopia
title_sort abo blood group and plasmodium falciparum malaria in awash, metehara and ziway areas, ethiopia
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020677/
https://www.ncbi.nlm.nih.gov/pubmed/20939876
http://dx.doi.org/10.1186/1475-2875-9-280
work_keys_str_mv AT tekestezinaye theabobloodgroupandplasmodiumfalciparummalariainawashmeteharaandziwayareasethiopia
AT petrosbeyene theabobloodgroupandplasmodiumfalciparummalariainawashmeteharaandziwayareasethiopia
AT tekestezinaye abobloodgroupandplasmodiumfalciparummalariainawashmeteharaandziwayareasethiopia
AT petrosbeyene abobloodgroupandplasmodiumfalciparummalariainawashmeteharaandziwayareasethiopia