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Regulated Phosphorylation of a Major UDP-glucuronosyltransferase Isozyme by Tyrosine Kinases Dictates Endogenous Substrate Selection for Detoxification

Whereas UDP-glucuronosyltransferase-2B7 is widely distributed in different tissues, it preferentially detoxifies genotoxic 4-OH-estradiol and 4-OH-estrone (4-OHE(1)) with barely detectable 17β-estradiol (E(2)) conversion following expression in COS-1 cells. Consistent with the UDP-glucuronosyltransf...

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Detalles Bibliográficos
Autores principales:	Mitra, Partha S., Basu, Nikhil K., Basu, Mousumi, Chakraborty, Sunit, Saha, Tapas, Owens, Ida S.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020772/ https://www.ncbi.nlm.nih.gov/pubmed/21056984 http://dx.doi.org/10.1074/jbc.M110.165126

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