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Cross-Regulation between Oncogenic BRAF(V600E) Kinase and the MST1 Pathway in Papillary Thyroid Carcinoma

BACKGROUND: The BRAF(V600E) mutation leading to constitutive signaling of MEK-ERK pathways causes papillary thyroid cancer (PTC). Ras association domain family 1A (RASSF1A), which is an important regulator of MST1 tumor suppressor pathways, is inactivated by hypermethylation of its promoter region i...

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Detalles Bibliográficos
Autores principales:	Lee, Seong Jin, Lee, Min Hee, Kim, Dong Wook, Lee, SeongEun, Huang, Songmei, Ryu, Min Jeong, Kim, Yong Kyung, Kim, Sung Jin, Kim, Soung Jung, Hwang, Jung Hwan, Oh, Sangphil, Cho, Heeyeong, Kim, Jin Man, Lim, Dae-Sik, Jo, Young Suk, Shong, Minho
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020965/ https://www.ncbi.nlm.nih.gov/pubmed/21249150 http://dx.doi.org/10.1371/journal.pone.0016180

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