Development of an oncolytic Herpes Simplex Virus using a tumor-specific HIF-responsive promoter

We exploited the differential activation of hypoxia-inducible factor (HIF)-dependent gene expression in tumors versus normal tissue for the design of a targeted oncolytic Herpes simplex virus type-1 (HSV-1). A gene that is essential for viral replication, ICP4, was placed under the regulation of a H...

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Detalles Bibliográficos
Autores principales: Longo, Sharon L., Griffith, Christopher, Glass, Aaron, Shillitoe, Edward J., Post, Dawn E.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021095/
https://www.ncbi.nlm.nih.gov/pubmed/20930860
http://dx.doi.org/10.1038/cgt.2010.62

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