Regulation of Benzo[a]pyrene-Mediated DNA- and Glutathione-Adduct Formation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Human Lung Cells

[Image: see text] Environmental carcinogens, such as polycyclic aromatic hydrocarbons (PAHs), require metabolic activation to DNA-reactive metabolites in order to exert their tumorigenic effects. Benzo[a]pyrene (B[a]P), a prototypic PAH, is metabolized by cytochrome P450 (P450) 1A1/1B1 and epoxide h...

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Detalles Bibliográficos
Autores principales: Gelhaus, Stacy L., Harvey, Ronald G., Penning, Trevor M., Blair, Ian A.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021323/
https://www.ncbi.nlm.nih.gov/pubmed/21028851
http://dx.doi.org/10.1021/tx100297z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021323/
https://www.ncbi.nlm.nih.gov/pubmed/21028851
http://dx.doi.org/10.1021/tx100297z

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