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Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies

[Image: see text] To facilitate the discovery of clinically useful Stat3 inhibitors, computational analysis of the binding to Stat3 of the existing Stat3 dimerization disruptors and quantitative structure−activity relationships (QSAR) were pursued, by which a pharmacophore model was derived for pred...

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Detalles Bibliográficos
Autores principales:	Shahani, Vijay M., Yue, Peibin, Haftchenary, Sina, Zhao, Wei, Lukkarila, Julie L., Zhang, Xiaolei, Ball, Daniel, Nona, Christina, Gunning, Patrick T., Turkson, James
Formato:	Texto
Lenguaje:	English
Publicado:	American Chemical Society 2010
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021410/ https://www.ncbi.nlm.nih.gov/pubmed/21243039 http://dx.doi.org/10.1021/ml100224d

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