Mutation of HIV-1 Genomes in a Clinical Population Treated with the Mutagenic Nucleoside KP1461

The deoxycytidine analog KP1212, and its prodrug KP1461, are prototypes of a new class of antiretroviral drugs designed to increase viral mutation rates, with the goal of eventually causing the collapse of the viral population. Here we present an extensive analysis of viral sequences from HIV-1 infe...

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Detalles Bibliográficos
Autores principales: Mullins, James I., Heath, Laura, Hughes, James P., Kicha, Jessica, Styrchak, Sheila, Wong, Kim G., Rao, Ushnal, Hansen, Alexis, Harris, Kevin S., Laurent, Jean-Pierre, Li, Deyu, Simpson, Jeffrey H., Essigmann, John M., Loeb, Lawrence A., Parkins, Jeffrey
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021505/
https://www.ncbi.nlm.nih.gov/pubmed/21264288
http://dx.doi.org/10.1371/journal.pone.0015135

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