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Analysis of the Ex Vivo and In Vivo Antiretroviral Activity of Gemcitabine

Replication of retroviral and host genomes requires ribonucleotide reductase to convert rNTPs to dNTPs, which are then used as substrates for DNA synthesis. Inhibition of ribonucleotide reductase by hydroxyurea (HU) has been previously used to treat cancers as well as HIV. However, the use of HU as...

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Detalles Bibliográficos
Autores principales:	Clouser, Christine L., Holtz, Colleen M., Mullett, Mary, Crankshaw, Duane L., Briggs, Jacquie E., Chauhan, Jay, VanHoutan, Ilze Matise, Patterson, Steven E., Mansky, Louis M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021508/ https://www.ncbi.nlm.nih.gov/pubmed/21264291 http://dx.doi.org/10.1371/journal.pone.0015840

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