Paradoxical Increase in TAG and DAG Content Parallel the Insulin Sensitizing Effect of Unilateral DGAT1 Overexpression in Rat Skeletal Muscle

BACKGROUND: The involvement of muscle triacylglycerol (TAG) storage in the onset of insulin resistance is questioned and the attention has shifted towards inhibition of insulin signalling by the lipid intermediate diacylglycerol (DAG). The enzyme 1,2-acylCoA:diacylglyceroltransferase-1 (DGAT1) ester...

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Detalles Bibliográficos
Autores principales: Timmers, Silvie, de Vogel-van den Bosch, Johan, Hesselink, Matthijs K. C., van Beurden, Denis, Schaart, Gert, Ferraz, Maria Joao, Losen, Mario, Martinez-Martinez, Pilar, De Baets, Marc H., Aerts, Johannes M. F. G., Schrauwen, Patrick
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021516/
https://www.ncbi.nlm.nih.gov/pubmed/21264296
http://dx.doi.org/10.1371/journal.pone.0014503

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