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The Antiviral Spectra of TRIM5α Orthologues and Human TRIM Family Proteins against Lentiviral Production
BACKGROUND: Rhesus monkey TRIM5α (TRIM5αrh) recognizes the incoming HIV-1 core through its C-terminal B30.2(PRYSPRY) domain and promotes its premature disassembly or degradation before reverse transcription. Previously, we have shown that TRIM5αrh blocks HIV-1 production through the N-terminal RBCC...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021539/ https://www.ncbi.nlm.nih.gov/pubmed/21264255 http://dx.doi.org/10.1371/journal.pone.0016121 |